CAS: 571189-49-6; 5-(4-Methylpiperazin-1-yl)Pyridin-2-Amine

相似化合物

571188-59-5 657410-79-2 866620-36-2

上下游产品

CAS号657410-79-2 1-甲基-4-(6-硝基吡啶-... | CAS号39856-50-3 5-溴-2-硝基吡啶 | CAS号109-01-3 N-甲基哌嗪

5-溴-2-硝基吡啶置于palladium 10% On Activated Carbon,四丁基溴化铵,氢气,Potassium Carbonate体系中,用 甲醇,二甲基亚砜 作为反应溶剂,化学反应 12.0H,反应生成 1-甲基-4-(6-氨基吡啶-3-基)哌嗪
参考文献:设计,合成和评估新型5-苯基吡啶-2(1 H)-One衍生物作为强效可逆布鲁顿酪氨酸激酶抑制剂
标题:设计,合成和评估新型5-苯基吡啶-2(1 H)-One衍生物作为强效可逆布鲁顿酪氨酸激酶抑制剂
摘要:根据最近报告的临床前药物rn486的结构设计了一系列新型可逆性btk抑制剂.描述了这些化合物的合成和sar.在这些衍生物中,化合物16B被确定为有效的口服可逆剂,在体外具有令人满意的btk酶和细胞抑制作用,在体内具有非常好的pk特性和对关节炎的抑制作用.
DOI:10.1016/j.Bmc.2014.11.006

专利信息

专利号:US-12006324-B1
优先权日:2022-12-15
标题:Preparation method of trilaciclib and precursors of trilaciclib
发明人：KAMANI SATYANARAYANA; CHANG HSIN-YUN; LU TZU-CHIANG; MAI CHIN-CHENG
权利人:CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:Disclosed herein is a specific method of preparation of Trilaciclib. The said method is to provide an efficacy of a protection free synthetic method of Trilaciclib with less steps and good yields.

专利号:US-11629150-B2
优先权日:2016-07-01
标题:Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
发明人：SMITH ALEXANDER; WHITE HANNAH S; TAVARES FRANCIS XAVIER; KRASUTSKY SERGIY; CHEN JIAN-XIE; DORROW ROBERTA L; ZHONG HUA
权利人:G1 THERAPEUTICS INC
摘要:This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

专利号:WO-2024116069-A1
优先权日:2022-11-28
标题 :Novel trilaciclib intermediates, method of preparation and use thereof
发明人：KADU Rushikesh Vilasrao; RENGASAMY VADIVELANV; SINGH SATNAM; SHARMA SUBRAMANYA; DAUND VAIBHAV SURESH; KUSHWAHA SANDEEP; LAL KANHAIYA; YAZALI VENKATA SUBBARAO
权利人:ASSIA CHEM IND LTD
摘要:Aspects of the present disclosure provide novel intermediates that may be used for synthesis of Trilaciclib, pharmaceutically acceptable salts or derivatives thereof. Aspects of the present disclosure also relate to a method for preparation of Trilaciclib intermediates. Further aspects of the present disclosure relate to method for preparation of Trilaciclib, pharmaceutically acceptable salts and derivatives thereof. Still further aspects of the present disclosure are drawn towards use of the Trilaciclib intermediates for the production of Trilaciclib, pharmaceutically acceptable salts or derivatives thereof.

专利号:WO-2018005865-A1
优先权日:2016-07-01
标 题 :Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines

专利号:CN-113788837-A
优先权日:2021-08-02
标题 :Synthesis of Trilaciclib

专利号:US-2021122755-A1
优先权日:2016-07-01
标 题:Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines