专利号:US-2012177593-A1 优先权日:2009-07-20 标 题 :Synthesis of dendrimer conjugates 发明人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH 权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN 摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
专利号:US-2014255328-A1 优先权日:2013-03-11 标 题:Hydrothermal Synthesis of Zinc Phlogopite 发明人:MCGUIRE MEAGHAN CLARK; BULL IVOR; JOHNSON GEOFFREY MARK 权利人:BASF SE 摘要:This invention relates to a synthetically derived zinc phlogopite platelets, of superior platelet diameter, effect pigments comprising such synthetically derived platelets and methods of forming said substrates. More specifically the disclosure describes an improved hydrothermal synthesis of zinc phlogopite suitable as a platelets for interference pigments, barrier and flame retardant applications.
专利号:EP-2021360-B1 优先权日:2006-04-26 标 题:CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(TYR-Xaa) CYCLODIPEPTIDES 发明人:BELIN PASCAL; GONDRY MURIEL; THAI ROBERT; PERNODET JEAN-LUC; GENET ROGER 权利人:COMMISSARIAT ENERGIE ATOMIQUE; KYOWA HAKKO BIO CO LTD; UNIV PARIS SUD 11; CENTRE NAT RECH SCIENT 摘要:Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof.
专利号:US-10603381-B2 优先权日:2014-10-10 标 题:Synthesis of nanocompounds comprising anatase-phase titanium oxide and compositions containing same for the treatment of cancer 发明人:CAMARGO AMADO RUBÉN JESÚS; GUTIÉRREZ MONTES JOSÉ OSCAR; BASANTE ROMO MÓNICA JIMENA; CRIOLLO GÓMEZ WILLIAM DAVID 权利人:UNIV DEL VALLE 摘要:This invention relates to novel nanocompounds that are cytotoxic to tumor cells when combined with ultraviolet light, the nanocompounds comprising multilayered carbon nanotubes with anatase-phase titanium dioxide or anatase-phase titanium dioxide and folate. The invention also relates to a composition containing said nanocompounds and to a method for the treatment of cancer; comprising the administration of said composition in co-treatment with UV radiation. The invention further relates to a method for the synthesis of the nano-compounds.
专利号:EP-2021357-B1 优先权日:2006-04-26 标 题:Cyclodipeptide synthetases and their use for synthesis of cyclo(leu-leu) cyclodipeptide 发明人:GONDRY MURIEL; THAI ROBERT; BELIN PASCAL; GENET ROGER; PERNODET JEAN-LUC 权利人:COMMISSARIAT ENERGIE ATOMIQUE; KYOWA HAKKO BIO CO LTD; UNIV PARIS SUD; CENTRE NAT RECH SCIENT 摘要:Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said polynucleotides or any substantially homologous polynucleotides, the host cell modified with said polynucleotides or said recombinant vectors and also methods for in vitro and in vivo synthesizing cyclo(Leu-Leu) cyclodipeptide and its derivatives and applications thereof.
专利号:EP-0948511-B1 优先权日:1996-12-24 标 题:Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides 发明人:KARPEISKY ALEXANDER; BEIGELMAN LEONID; MATULIC-ADAMIC JASENKA 权利人:SIRNA THERAPEUTICS INC 摘要:Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed. Also described are polynucleotides, such as antisense, TFO and nucleic acid catalysts with one or more modifications, such as 2'-O-amino, L-nucleotides and the others.
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