CAS: 618-88-2; 5-Nitroisophthalic Acid

相似化合物

13290-96-5 99-31-0 172899-78-4

上下游产品

CAS号121-91-5 间苯二甲酸(IPA) | CAS号121-92-6 间硝基苯甲酸 | CAS号99-12-7 3,5-二甲基硝基苯 | CAS号108-38-3 间二甲苯 | CAS号7697-37-2 硝酸 | CAS号146335-23-1 5-CYANO-1,3-DIH... | CAS号146335-25-3 (3-氨基-5-甲基苯基)甲醇 | CAS号41642-51-7 分散兰BBLS | CAS号42122-73-6 5-氨基间苯二甲酸二乙酯 | CAS号1955-04-0 3-甲酰氯-5-硝基苯甲酸甲酯 | CAS号2157-39-3 5-氯间苯二甲酸 | CAS号20033-48-1 2,6-二氰基-4-硝基苯胺 | CAS号99-27-4 5-氨基间苯二甲酸二甲酯 | CAS号79370-78-8 5-羟基-1,3-苯二醛 | CAS号99-31-0 5-氨基间苯二甲酸

5-硝基间二甲苯置于铬酸体系中,化学反应生成 5-硝基异酞酸
参考文献:Wroblewski,Chemische Berichte,1882,Vol. 15,P. 1022
标题:Wroblewski,Chemische Berichte,1882,Vol. 15,P. 1022

专利信息

专利号:US-8969619-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in propyleneglycol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; KJERNLI TROND; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with propyleneglycol as solvent.

专利号:US-2011021821-A1
优先权日:2009-07-21
标题:Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
发明人：CERVENKA JAN; HUSSAIN KHALID
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by the removal of acetic anhydride.

专利号:US-7696381-B1
优先权日:2009-07-21
标题 :Alternative dimerisation reagents for synthesis of iodixanol
发明人：BERG ARNE; DUGSTAD HARALD; GACEK MICHEL; GULBRANDSEN TRYGVE; STRANDE PER
权利人:GE HEALTHCARE AS
摘要:This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?) to iodixanol.

专利号:US-8962886-B2
优先权日:2009-07-21
标题:Synthesis of iodixanol in methanol
发明人：JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE
权利人:JOHNSEN HANNE JORUNN H; HOLMAAS LARS TERJE; HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with methanol as solvent.

专利号:US-8962887-B2
优先权日:2009-07-21
标题 :Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
发明人：HOMESTAD OLE MAGNE
权利人:HOMESTAD OLE MAGNE; GE HEALTHCARE AS
摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.

专利号:US-2011021822-A1
优先权日:2009-07-21
标题:continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
发明人：ASKILDSEN ARNE; CERVENKA JAN; HUSSAIN KHALID; SORENSEN THORE JARLE; MALTHE-SORENSSEN DIDRIK
权利人:GE HEALTHCARE AS
摘要:This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound Aâ€?), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of deacetylation of the acetylated hydroxyl group in 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound Bâ€?) followed by crystallisations, filtration, and washing of Compound A.