CAS: 84030-20-6; 7-Methyl-1,5,7-Triazabicyclo[4.4.0]Dec-5-Ene

相似化合物

5807-14-7 1695731-27-1 1690859-94-9

上下游产品

1,5,7-三氮杂双环[4.4.0]癸-5-烯 1,3,4,6,7,8-Hexahydro-2H-Pyrimido[1,2-A]Pyrimidine 5807-14-7

3,3'-二氨基二丙基胺置于原碳酸四乙酯,氢溴酸,Sodium Methylate,Sodium Hydride体系中,用 四氢呋喃,乙醇,二甲基亚砜 作为反应溶剂,化学反应 40.0H,反应生成 7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯
参考文献:一种7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯的合成方法
标题:一种7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯的合成方法
摘要:本发明公开了一种7‑甲基‑1,5,7‑三氮杂二环[4.4.0]癸‑5‑烯的合成方法:在四氢呋喃中3,3'‑二氨基二丙胺与氢溴酸溶液成盐,以二甲亚砜作为反应溶剂,与原碳酸四乙酯,3,3'‑二氨基二丙胺加热反应;反应结束后,加入四氢呋喃析晶,抽滤,悬洗,干燥得到中间体化合物ⅳ;然后与甲醇钠反应,游离后得到粗品化合物ⅴ,化合物ⅴ通过甲苯结晶提纯后再在碱作用下,与硫酸二甲酯反应得到粗品目标化合物ⅵ;将粗品进行减压蒸馏,收集80~85oc/55Pa馏分,得到无色透明液体.本发明制得的高纯度7‑甲基‑1,5,7‑三氮杂二环[4.4.0]癸‑5‑烯,Gc纯度能达到99%以上,总收率79%以上.

专利信息

专利号:US-11230560-B2
优先权日:2017-05-22
标题 :Synthesis of ETP derivatives
发明人：HORNE DAVID; XIE JUN
权利人:HOPE CITY
摘要:Provided herein, inter alia, is the synthesis of ETP derivatives. The synthetic methods described herein include converting a ring bridging trisulfide compound of formula n nto a ring bridging disulfide compound of formulan n nAlso provided herein are compositions comprising thereof.

专利号:US-2010191010-A1
优先权日:2007-07-02
标题 :Process for the synthesis of carbamates using co2
发明人：BOSMAN JORIS KAREL PETER; CARR ROBERT HENRY
权利人:HUNTSMAN INT LLC
摘要:Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO 2 in the presence of ionic liquids and optionally in the presence of a base.

专利号:US-12054508-B1
优先权日:2019-04-16
标 题 :Compositions and methods for sulfation of carbohydrates and peptides via electron-deficient aryl sulfate diesters
发明人：NIU JIA; LIU CHAO; YANG CANGJIE
权利人:THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a facile strategy to introduce electron-deficient aryl sulfate diesters to silylated hydroxyl groups of carbohydrates and amino acids, among other substrates, wherein selective hydrolysis and the removal of an electron-deficient aromatic group allows for the efficient generation of sulfated carbohydrates, peptides, and other compounds. The incorporation of electron-deficient aryl sulfate diesters in the early stage of the synthesis of glycans, peptides, and the like, disclosed herein avoids time-consuming protecting group manipulations, simplifies the purification of sulfated products, and improves the overall yield and efficiency. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-2024327320-A1
优先权日:2023-02-06
标 题:Novel routes of chemical synthesis of 20s(oh)d3, 20s,25(oh)2d3, 20s,23s(oh)2d3, and 20s,23r(oh)2d3 and their modification of the immune activity of pbmcs
发明人：SLOMINSKI ANDRZEJ; BRZEMINSKI PAWEL; FABISIAK ADRIAN
权利人:UNITED STATE GOVERNMENT AS REPRESEN TED BY THE DEPT OF VETERANS AFFAIRS; UNIV OF WARSAW
摘要:The present disclosure is concerned with methods of making hydroxy derivatives of vitamin D3, compounds useful as intermediates in the preparation of the hydroxy derivatives, and methods of making the intermediates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-12304885-B2
优先权日:2022-04-20
标 题:Synthesis and purification of CBDA
发明人：SHEARER RANDALL L
权利人:UNIV COLORADO REGENTS; UNIV COLORADO REGENTS
摘要:Methods and systems for the preparation of high purity and high quality cannabinoid acids and metal salts of cannabinoids. Cannabidiolic acid (CBDA) is a major cannabinoid of interest for and health reasons. It is the natural precursor of cannabidiol (CBD). The invention provides methods for the synthesis of CBDA from CBD with reagents that produce a high purity product without need for further purification. Insertion of a magnesium complexing agent prior to conversion of the reaction intermediate to the final acid product produces a high purity product with aesthetically pleasing white color and neutral odor. Methods are provided for the simultaneous synthesis and purification of cannabinoid acids, especially CBDA, produced from high purity CBD (or other cannabinoid) via a Kolbe-Schmitt type reaction using an organic base, such as DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), incorporating complexation of acid anions to a multivalent metal, alkaline earth or transition metal, prior to product acid work-up. During the work-up to the final acid, the distinct solubility of the complex in selected solvents is used advantageously to first exclude water soluble reagents and impurities and next to exclude lipophilic hydroxyl-quinone impurities, as well as any unconverted CBD.

专利号:US-5130447-A
优先权日:1988-12-23
标题:Process for the synthesis of N.sup.α -fluorenylmethoxycarbonyl-NG trityl-arginine
发明人：CACIAGLI VALERIO; VERDINI ANTONIO S
权利人:SCLAVO SPA
摘要:An improvement is described in the synthesis method for N.sup.α -trityl-N G -trityl arginine within a process for preparing N.sup.α -fluorenylmethoxycarbonyl-N G -trityl-arginine from arginine, comprising: n a) forming N.sup.α -trityl-N G -trityl-arginine n b) selectively detaching the trityl group from the α-NH 2 and n c) introducing the fluorenylmethoxycarbonyl group in its place. n The improvement consists of preparing the N.sup.α -trityl-N G -trityl-arginine by solubilizing the arginine in an aprotic organic solvent by tri-alkylsilylation both of the amino nitrogen and of the carboxyl group, followed by tritylation, with trityl chloride, of the α-amino nitrogen, and of the guanidino group after deprotonating this latter with a bicyclic guanidine. The new improved process can also lead to variable quantities of the arginine analogue di-tritylated at the guanidino group, namely N.sup.α -fluorenylmethoxycarbonyl-N G -di-trityl-arginine. This new compound, to which the present invention also relates, can also be used as such in peptide synthesis.