CAS: 99368-66-8; 5-Nitro-3-(Trifluoromethyl)Pyridin-2-Ol

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参考文献:Solid Dispersions Containing An Apoptosis-Inducing Agent
标题:Solid Dispersions Containing An Apoptosis-Inducing Agent
摘要:一种促凋亡的固体分散体包括本文所定义的具有本文所述的化学式i的bcl-2家族蛋白抑制化合物,以基本非晶态形式分散在包括(a)药学上可接受的水溶性聚合物载体和(b)药学上可接受的表面活性剂的固体基质中.制备这种固体分散体的方法包括在合适的溶剂中溶解化合物,聚合物载体和表面活性剂,并去除溶剂以提供包括聚合物载体和表面活性剂并在其中以基本非晶态形式分散有化合物的固体基质.这种固体分散体适用于口服给予需要治疗由一个或多个抗凋亡bcl-2家族蛋白过度表达所特征的疾病的受试者,例如癌症.

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:WO-2008119015-A2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins

专利号:US-8987452-B2
优先权日:2007-03-27
标 题:Synthesis of thiohydantoins

专利号:US-2010190991-A1
优先权日:2007-03-27
标题 :Synthesis of thiohydantoins

专利号:US-9512103-B2
优先权日:2007-03-27
标题:Synthesis of thiohydantoins

专利号:US-2015191449-A1
优先权日:2007-03-27
标题:Synthesis of thiohydantoins