CAS: 103-81-1; 2-Phenylacetamide

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151059-43-7 74860-13-2 6633-76-7

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CAS号536-74-3 苯乙炔 | CAS号122-78-1 2-苯基乙醛 | CAS号98-86-2 苯乙酮 | CAS号292638-84-7 phenylene-ethylene | CAS号103-82-2 苯乙酸 | CAS号140-29-4 苯乙腈 | CAS号103-80-0 苯乙酰氯 | CAS号101-97-3 苯乙酸乙酯 | CAS号90-82-4 伪麻黄碱 | CAS号30516-21-3 1-(1H-1,2,3-ben... | CAS号3173-56-6 异氰酸苄酯 | CAS号103-82-2 苯乙酸 | CAS号673-06-3 D-苯丙氨酸 | CAS号738-75-0 N-(苯乙酰)-L-苯丙氨酸 | CAS号56613-61-7 4-硝基-D-苯丙氨酸 | CAS号14091-08-8 D-4-氯苯丙氨酸 | CAS号18125-46-7 4-氟-D-苯丙氨酸

苯乙酰胺,N-(1,1-二甲基乙基)-置于三氟乙酸体系中,用82%的收率获得2-苯乙酰胺
参考文献:N-甲苯磺酰azo与异氰酸酯的钯催化酰胺化
标题:N-甲苯磺酰azo与异氰酸酯的钯催化酰胺化
摘要:N-甲苯磺酰hydr的氨基羰基化作用:由卡宾和异氰酸酯直接形成酮亚胺的过程仅限于fischer卡宾配合物或某些特别稳定的卡宾与异氰化物的反应.描述了在水的存在下,通过一个烯酮亚胺中间体,钯催化的n-甲苯磺酰with与异氰酸酯的酰胺化反应.该方法提供了通过单碳延伸从羰基化合物合成酰胺的通用方法(参见方案).
Doi:10.1002/chem.201102459

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-5623068-A
优先权日:1994-03-07
标 题:Synthesis of DNA using substituted phenylacetyl-protected nucleotides
发明人：REDDY M PARAMESWARA; FAROOQUI FIRDOUS; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Deoxyribonucleotide and ribonucleotide derivatives of the general formula I I wherein R1 represents -CR'R''-Ar, in which Ar is substituted aryl (as hereinafter defined) and R' and R'' are independently selected from the group consisting of hydrogen and lower alkyl; one of -R2 and R3 is a hydroxyl-protecting group and the other is a group suitable for synthesis of polynucleotides or for attachment of the nucleotide to a solid support; R4 is selected from the group consisting of hydrogen, -OH and protected hydroxyl; and B represents a divalent radical corresponding to a purine or pyrimidine base. When synthesis is carried out using these derivatives, the deprotection procedure is reduced to an essentially instantaneous process. The derivatives have acceptable shelf life and are very stable to conventional DNA synthesis conditions. Particularly preferred are those compounds wherein Ar is mono- and dihalo-substituted phenyl.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.