CAS: 135242-93-2; (1-Methyl-1H-[1,2,4]Triazol-3-yl)Methanol

相似化合物

57031-66-0 815588-82-0 126748-87-6

上下游产品

1-甲基-1H-1,2,4-噻唑-3-羧酸 1-Methyl-1H-1,2,4-Triazole-3-Carboxylic Acid 815588-82-0
1-甲基-1H-1,2,4-三唑-3-甲酸甲酯 Methyl 1-Methyl-1H-1,2,4-Triazole-3-Carboxylate 57031-66-0
3-Tert-Butyldimethylsilyloxymethyl-1-Methyl-1H-1,2,4-Triazole 135206-74-5

3-Tert-Butyldimethylsilyloxymethyl-1-Methyl-1H-1,2,4-Triazole置于sodium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 48.0H,以100%的收率获得(1-甲基-1H-[1,2,4]噻唑-3-基)-甲醇
参考文献:Optically Active Antifungal Azoles. Iii. Synthesis And Antifungal Activity Of Sulfide And Sulfonamide Derivatives Of (2R,3R)-2-(2,4-Difluorophenyl)-3-Mercapto-1-(Lh-1,2,4-Triazol-1-yl)-2-Butanol.
标题:Optically Active Antifungal Azoles. Iii. Synthesis And Antifungal Activity Of Sulfide And Sulfonamide Derivatives Of (2R,3R)-2-(2,4-Difluorophenyl)-3-Mercapto-1-(Lh-1,2,4-Triazol-1-yl)-2-Butanol.
摘要:为了寻找强效的抗真菌剂,制备并评估了对光学活性含硫三唑衍生物,硫醚(3)和磺胺(4)对白色念珠菌的体外和体内抗真菌活性.硫醚(3)是通过(2R,3R)-2-(2,4-二氟苯基)-3-巯基-1-(1H,1,2,4-三唑-1-基)-2-丁醇(1)与各种杂芳基氯甲烷在甲醇钠存在下反应制备的.磺胺(4)是从二硫化物(15)开始以三个步骤合成的,包括相应亚磺酰胺(17)的氧化.一些含硫三唑衍生物(3,4)显示出对小鼠念珠菌病的强烈保护作用.
Doi:10.1248/cpb.42.85

专利信息

专利号:EP-0302633-A2
优先权日:1987-08-07
标 题:Beta-lactam compound, process for preparing the same, intermediate for synthesis of the same and medicinal composition for bacterially infectious disease therapy containing the same

专利号:CN-114805314-B
优先权日:2022-04-20
标 题:A kind of synthesis method of ensetvir

专利号:RU-2039050-C1
优先权日:1989-09-26
标 题:Derivatives of 1,2,4-triazole, optically inert or containing r- or s-configuration at c-2 and c-3 asymmetric centers, or their salts showing fungicide activity, and a method of their synthesis

专利号:CN-116891459-A
优先权日:2022-04-08
标 题:Synthesis method of polysubstituted triazinane compound