CAS: 14192-26-8; Methyl 2-Oxoindoline-6-Carboxylate

相似化合物

334952-09-9 954239-49-7 199328-10-4

上下游产品

CAS号334952-07-7 4-(2-甲氧基-2-氧代乙基... | CAS号1160293-27-5 2-[4-甲氧羰基-2-硝基苯... | CAS号67-56-1 甲醇 | CAS号334952-09-9 2-氧代吲哚啉-6-甲酸 | CAS号334952-09-9 2-氧代吲哚啉-6-甲酸 | CAS号656247-17-5 尼达尼布 | CAS号676326-36-6 1-乙酰基-2,3-二氢-2-...

间硝基苯甲酸置于硫酸,Palladium On Activated Charcoal,Potassium Tert-Butylate,氢气,溶剂黄146体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成2-氧化吲哚-6-甲酸甲酯
参考文献:用于改善药代动力学特性的氘代尼达尼布的设计,合成和生物学评价
标题:用于改善药代动力学特性的氘代尼达尼布的设计,合成和生物学评价
摘要:尼达尼布是一种新型三联血管激酶抑制剂,可同时抑制三种生长因子.在体外和体内制备和评估了某些代谢活性位点的尼达尼布氘代衍生物.特别是,与尼达尼布相比,氘代化合物 Sklb-C2202 具有显着改善的药代动力学特性.这些努力为进一步研究 Sklb-C2202 的成药性奠定了基础.
Doi:10.1002/jlcr.3299

专利信息

专利号:US-11261158-B2
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives
发明人：PIISOLA ANTTI; TOIS JAN
权利人:FERMION OY
摘要:The present disclosure relates to a preparation method of methyl (E)-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate from methyl 2-oxoindoline-6-carboxylate using high reaction temperatures and a reaction solvent enabling azeotropic removal of acetic acid during the reaction.

专利号:CN-111465594-A
优先权日:2017-11-17
标 题 :Synthesis of 2-indolinones known as intermediates for the preparation of nintedanib

专利号:WO-2019097112-A1
优先权日:2017-11-17
标题:Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib

专利号:JP-2023171763-A
优先权日:2017-11-17
标 题:Synthesis of 2-indolinone derivatives known as intermediates for producing nintedanib

专利号:CN-111465594-B
优先权日:2017-11-17
标题:Synthesis of 2-indolinones known as intermediates for the preparation of Nidamibu

专利号:EP-3710427-A1
优先权日:2017-11-17
标 题:Synthesis of a 2-indolinone derivative known as intermediate for preparing nintedanib