CAS: 172673-20-0; Fosaprepitant

专利信息

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-2010160247-A1
优先权日:2008-06-17
标题 :Synthesis of deuterated morpholine derivatives

专利号:US-9453009-B2
优先权日:2008-06-17
标题 :Synthesis of deuterated morpholine derivatives
发明人：LIU JULIE F; TANG XUEJUN; HARBESON SCOTT L; MASSE CRAIG E
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention is directed to a process for preparing a 2,26,6-d 4 -morpholine derivative represented by Structural Formula (I): n nor a salt thereof.

专利号:US-2015099714-A1
优先权日:2008-06-17
标 题 :Synthesis of deuterated morpholine derivatives

专利号:US-8354557-B2
优先权日:2008-06-17
标题 :Synthesis of deuterated morpholine derivatives

专利号:WO-2009154754-A2
优先权日:2008-06-17
标题:Synthesis of deuterated morpholine derivatives