CAS: 172732-52-4; 2-(1,3,2-Dioxaborinan-2-yl)Benzonitrile

上下游产品

2-氰基苯硼酸 2-Cyanophenylboronic Acid 138642-62-3

2-溴苯腈置于盐酸体系中,用 四氢呋喃,醋酸异丙酯,水,甲苯 用作溶剂,化学反应 5.25H,反应生成2-氰基苯硼酸 1,3-丙二醇酯
参考文献:Process For The Preparation Of 2-Cyanophenylboronic Acid And Esters Thereof
标题:Process For The Preparation Of 2-Cyanophenylboronic Acid And Esters Thereof
摘要:本发明涉及一种合成2-氰基苯硼酸及其酯和盐的方法,其化合物为合成活性药物成分如perampanel或e2040的中间体,其化学式为(II):(II).

专利信息

专利号:US-9000205-B2
优先权日:2012-08-06
标题:Process for the preparation of 2-cyanophenylboronic acid and esters thereof
发明人：FONTANA FRANCESCO; ROSSI EMILIANO; DE FILIPPO CHRISTIAN
权利人:F I S —FABBRICA ITALIANA SINT S P A
摘要:The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof of formula (II), which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040. formula (II): (II).

专利号:EP-3560934-A1
优先权日:2018-04-26
标题:Process for the preparation of pure 2-cyanophenylboronic acid and esters thereof, intermediates of perampanel or of e2040
发明人：FONTANA FRANCESCO; DI PIETRO FEDERICO; NALIN ARNALDO
权利人:FIS FABBRICA ITALIANA SINTETICI SPA
摘要:The present invention relates to a process for the synthesis of 2-cyanophenylboronic acid and the esters and salts thereof, which are intermediates of the synthesis of active pharmaceutical ingredients such as Perampanel or E2040, wherein impurity formation, in particular the formation of DBBN iPrketone, is reduced.

专利号:US-10111867-B2
优先权日:2015-02-17
标题:Process and intermediates for the preparation of perampanel
发明人：MAROM EHUD; RUBNOV SHAI
权利人:MAPI PHARMA LTD
摘要:The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.

专利号:US-9695147-B2
优先权日:2013-07-25
标题 :Process for the preparation of perampanel
发明人：BUCHLOVIC MARIAN
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present invention provides intermediates useful for the synthesis of Perampanel and processes employing said intermediates for preparing Perampanel. The invention also provides processes for making the intermediates, crystalline forms of the intermediates and the use of the crystalline forms for preparing Perampanel.