CAS: 177906-48-8; Trans-Tert-Butyl (4-Aminocyclohexyl)Carbamate

该化合物是一种化学化合物,其特点是其双环结构,其特点是环乙烷环环,其1和4位置上有两个有地雷功能的组群."N-Boc"的称谓表明,其中一个矿体组群受三丁基氧基碳基(Boc)组群的保护,该组群通常用于有机合成,以暂时遮盖胺并便利各种反应.该组群通常是白色到白色的固体,在二氯甲烷和二甲基硫氧化物等有机溶剂中可溶解.它经常用于合成药品和其他有机化合物,因为它能够成为形成更复杂的结构的建筑块.分子的变形结构有助于其分子和电子特性,影响其反应的再动性和化学反应的相互作用.和许多氨一样,它可能表现出基本性,并能够参与氢的结合,使它成为合成化学的灵敏性中间体.

英文名称Trans-Tert-Butyl (4-Aminocyclohexyl)Carbamate
中文名称N-Boc-反式-1,4-环己二胺
IUPAC名称tert-butyl ((1r,4r)-4-aminocyclohexyl)carbamate
其它别名Carbamicacid, (4-amin°Cyclohexyl)-, 1,1-dimethylethyl ester, trans-; Carbamic acid,(trans-4-amin°Cyclohexyl)-, 1,1-dimethylethyl ester (9CI); 1,1-Dimethylethyl(trans-4-amin°Cyclohexyl)carbamate; N-B°C-trans-1,4-cyclohexanediamine; N-tert-Butoxycarbonyl-trans-1,4-cyclohexanediamine; N-tert-Butoxycarbonyl-trans-1,4-cyclohexyldiamine; tert-Butyl(trans-4-amin°Cyclohexyl)carbamate; tert-Butyltrans-(4-amin°Cyclohexyl)carbamate; tert-Butyltrans-N-(4-amin°Cyclohexyl)carbamate; trans-(4-Amin°Cyclohexyl)carbamic acidtert-butyl ester; trans-4-(tert-Butoxycarbonylamino)cyclohexylamine; trans-4-[(tert-Butoxycarbonyl)amino]-1-amin°Cyclohexane; trans-N-B°C-1,4-cyclohexanediamine; trans-tert-Butyl 4-amin°Cyclohexylcarbamate
CAS编号177906-48-8
MFCD编号:MFCD03001719
EINECS号:689-057-6
FDA UNII编号:C52FUP2E96
分子式:C11H22N2O2
分子量:214.3
产品CID: 905502
产品分类医药中间体 → 杂环化合物中间体 → 嘧啶类化合物 → 胺类

相似结构搜索
InChIKey: FEYLUKDSKVSMSZ-UHFFFAOYSA-N
InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9-…
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数4.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P280a-P304+P340-P305+P351+P338-P405-P501a

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2615-25-0 反式-1,4-环己二胺 | CAS号412357-45-0 tert-butyl ((1r... | CAS号108-91-8 环己胺 | CAS号296270-92-3 [反式-4-[[(1,1-二甲...

合成工艺路线路线简述

合成目标产物 Trans-N-Boc-1,4-Cyclohexanediamine 主要起始原料 Di-Tert-Butyl Dicarbonate And Trans-1,4-Diaminocyclohexane
24424-99-5 + 2615-25-0 = 177906-48-8
反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; 0 °C; 0 °C -> Rt; 24 H,Rt
标题:Switching On The Activity Of 1,5-Diaryl-Pyrrole Derivatives Against Drug-Resistant Eskape Bacteria: Structure-Activity Relationships And Mode Of Action Studies
作者:Masci,Domiziana; Hind,Charlotte; Islam,Mohammad K.; Toscani,Anita; Clifford,Melanie; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2019 卷标:178 页码:500-514]

24424-99-5 + 2615-25-0 = 177906-48-8
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 0 °C -> 23 °C; 15 H,23 °C
标题:Synthesis Of Flavin-Indole Conjugates With Rigid Diamino Linkers As Cryptochrome Model Compounds
作者:Schroder,Nils; Schmidtmann,Marc; Mouritsen,Henrik; Christoffers,Jens
参考文献:European Journal Of Organic Chemistry 日期:2023 卷标:26(7)]

24424-99-5 + 2615-25-0 = 177906-48-8
反应条件:1.1 Solvents: Chloroform; 0 °C -> Rt
标题:Development And Application Of A Near-Infrared Fluorescence Probe For Oxidative Stress Based On Differential Reactivity Of Linked Cyanine Dyes
作者:Oushiki,Daihi; Kojima,Hirotatsu; Terai,Takuya; Arita,Makoto; Hanaoka,Kenjiro; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(8) 页码:2795-2801

海关参考信息

2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2915110000-甲酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-Î± synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-Î± or by PDE4, including but not limited to psoriatic arthritis.

专利号:US-8003785-B2
优先权日:2008-06-18
标题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

专利号:US-8242142-B2
优先权日:2008-08-19
标题:Cyclohexylamines, phenylamines and uses thereof
发明人：LIN SHUO; YANG ZHEN
权利人:LIN SHUO; YANG ZHEN; UNIV CALIFORNIA; UNIV PEKING SHENZHEN GRAD SCHO
摘要:Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. n n n n n n n n n n Compositions including the compounds having the formula I-A in which the variables have the definitions described herein, and methods of using the compositions for the treatment of certain diseases mediated by the up-regulation of Smo are also disclosed.

专利号:WO-2009094528-A1
优先权日:2008-01-25
标题:TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-Î± SYNTHESIS AND AS PDE4 INHIBITORS

专利号:US-2012172381-A1
优先权日:2008-01-25
标题 :Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors