CAS: 44565-27-7; 4-Amino-2-Methylbutan-1-Ol

该化合物是一种多用途氨基酒精,可应用于有机合成和制药中间体.其结构以氨基和羟基功能组为特征,能够用作手性化合物和皮果的建筑块,用于非对称催化.该化合物的甲基替代会增强消毒影响,并有可能改善合成途径的选择性.它也用于准备生物活性分子,因为它能够形成稳定的衍生物.4-Amino-2-甲基-1-丁醇的平衡的体力和亲脂性有助于其溶解于各种溶剂,有助于将其融入多种反应条件.建议适当的处理和储存是因为它的被动功能组而有的.

结构式图片

相似化合物

88390-32-3 842146-73-0 1022985-41-6

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号201230-82-2 carbon monoxide | CAS号109-75-1 3-丁烯腈 | CAS号78-92-2 仲丁醇 | CAS号96192-37-9 (2R)-4-amino-2-... | CAS号42453-21-4 (D,l)-4-氨基-2-甲基-丁酸 | CAS号183551-55-5 (R)-3-METHYL-4-... | CAS号34375-89-8 3-甲基吡咯烷

合成工艺路线路线简述

    (D,L)-4-氨基-2-甲基-丁酸置于四氢呋喃,Lithium Aluminium Tetrahydride体系中,化学反应生成 4-氨基-2-甲基丁醇
    参考文献:The Absolute Configuration Of The C8-Atom In The Pyrrolizidine Moieties Of The Senecio Alkaloids
    标题:The Absolute Configuration Of The C8-Atom In The Pyrrolizidine Moieties Of The Senecio Alkaloids
    摘要:
    DOI:10.1021/ja01530A063

    海关参考信息

    专利信息


    专利号:US-2004053999-A1
    优先权日:1997-09-17
    标题 :Novel compounds and methods for synthesis and therapy
    发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
    摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

    专利号:US-6225341-B1
    优先权日:1995-02-27
    标 题:Compounds and methods for synthesis and therapy
    发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
    权利人:GILEAD SCIENCES INC
    摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

    专利号:US-9370515-B2
    优先权日:2013-03-07
    标题 :Mixed lineage kinase inhibitors and method of treatments
    发明人:GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
    权利人:CALIFIA BIO INC; UNIV ROCHESTER
    摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

    专利号:EP-2752422-B1
    优先权日:2010-03-31
    标题:Stereoselective synthesis of phosphorus containing actives

    专利号:CN-111848419-A
    优先权日:2020-07-28
    标 题 :(E) Synthesis method of -4-hydroxy-3-methyl-2-butenylamine and zeatin

    专利号:CN-111848419-B
    优先权日:2020-07-28
    标 题:(E) Synthesis method of (E) -4-hydroxy-3-methyl-2-butenylamine and zeatin
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    合成参考文献


    参考文献:10.1021/jo040128p
    摘要:Cobley CJ, Gardner K, Klosin J, Praquin C, Hill C, Whiteker GT, Zanotti-Gerosa A, Petersen JL, Abboud KA. Synthesis and application of a new bisphosphite ligand collection for asymmetric hydroformylation of allyl cyanide. J Org Chem. 2004 Jun 11;69(12):4031–40. doi: 10.1021/jo040128p.
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