(D,L)-4-氨基-2-甲基-丁酸置于四氢呋喃,Lithium Aluminium Tetrahydride体系中,化学反应生成 4-氨基-2-甲基丁醇 参考文献:The Absolute Configuration Of The C8-Atom In The Pyrrolizidine Moieties Of The Senecio Alkaloids 标题:The Absolute Configuration Of The C8-Atom In The Pyrrolizidine Moieties Of The Senecio Alkaloids 摘要: DOI:10.1021/ja01530A063
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-6225341-B1 优先权日:1995-02-27 标 题:Compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A 权利人:GILEAD SCIENCES INC 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-9370515-B2 优先权日:2013-03-07 标题 :Mixed lineage kinase inhibitors and method of treatments 发明人:GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A 权利人:CALIFIA BIO INC; UNIV ROCHESTER 摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.
专利号:EP-2752422-B1 优先权日:2010-03-31 标题:Stereoselective synthesis of phosphorus containing actives
专利号:CN-111848419-A 优先权日:2020-07-28 标 题 :(E) Synthesis method of -4-hydroxy-3-methyl-2-butenylamine and zeatin
专利号:CN-111848419-B 优先权日:2020-07-28 标 题:(E) Synthesis method of (E) -4-hydroxy-3-methyl-2-butenylamine and zeatin
参考文献:10.1021/jo040128p 摘要:Cobley CJ, Gardner K, Klosin J, Praquin C, Hill C, Whiteker GT, Zanotti-Gerosa A, Petersen JL, Abboud KA. Synthesis and application of a new bisphosphite ligand collection for asymmetric hydroformylation of allyl cyanide. J Org Chem. 2004 Jun 11;69(12):4031–40. doi: 10.1021/jo040128p.