CAS: 498-21-5; 2-Methylsuccinic Acid

相似化合物

2174-58-5 3641-51-8 1604-11-1

上下游产品

CAS号498-23-7 柠康酸 | CAS号97-65-4 衣康酸 | CAS号4457-71-0 3-甲基-1,5-戊二醇 | CAS号617-52-7 衣康酸二甲酯 | CAS号7338-27-4 衣康酸单甲酯 | CAS号1679-47-6 ALPHA-甲基-GAMMA-丁内酯 | CAS号498-24-8 中康酸 | CAS号127-17-3 丙酮酸 | CAS号87-69-4 酒石酸 | CAS号3641-51-8 (R)-(+)-甲基琥珀酸 | CAS号4100-80-5 2-甲基琥珀酸酐 | CAS号7732-18-5 水 | CAS号498-24-8 中康酸 | CAS号22644-27-5 (R)-(-)-2-甲基琥珀酸甲酯 | CAS号78-75-1 1,2-二溴丙烷 | CAS号616-44-4 3-甲基噻吩 | CAS号71-23-8 正丙醇 | CAS号187737-37-7 propene

柠檬酸置于水,氢气体系中,175.0 °C,3.2 Mpa 条件下,反应 24.0H,以91%的收率获得产物甲基丁二酸
参考文献:用于柠檬酸脱水-脱羧-加氢为甲基琥珀酸的稳定化镍催化剂
标题:用于柠檬酸脱水-脱羧-加氢为甲基琥珀酸的稳定化镍催化剂
摘要:最近,使用钯作为水中的贵金属催化剂,开发了一种脱水-脱羧-加氢将柠檬酸转化为甲基琥珀酸的新反应顺序.在这项工作中,作为低成本,非贵金属的替代品,对镍催化剂进行了研究.筛选了几种家用和商用催化剂用于该反应.柠檬酸是非常活泼的,在所有情况下都容易获得完全转化.然而,由于典型的ni催化剂不稳定并且因此不能氢化所形成的c C双键,因此对甲基琥珀酸的选择性最初较低.由于ni的氢化活性低于pd,因此出现了新的副产物.特别是c的水合在这种情况下,C双键使反应网络更复杂.幸运的是,所有水合产物的形成,甚至是相当稳定的内酯,β-羧基-γ-丁内酯,最终都被证明是完全可逆的.然后研究了三种途径来稳定镍催化剂并使镍催化的柠檬酸转化为甲基琥珀酸.对酸反应物进行部分中和,将铁添加到ni / Zro 2或反应混合物中,并用碳覆盖ni颗粒,都证明可以稳定ni,并且都可以产生很高或非常高的甲基琥珀酸收率.此外,通过与不同的
DOI:10.1039/c7Gc01773A

专利信息

专利号:WO-2009018504-A1
优先权日:2007-08-01
标题 :Process for the synthesis of diaminopyridine and related compounds
发明人：RITTER JOACHIM C
权利人:DU PONT; RITTER JOACHIM C
摘要:A process is provided for the synthesis of a diaminopyridine, such as 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-2004014180-A1
优先权日:2000-09-14
标 题 :Method for the microbial production of metabolic products, polynucleotides from coryneform bacteria and use thereof
发明人：BOTT MICHAEL; NIEBISCH AXEL; BATHE BRIGITTE; MARX ACHIM; HERMANN THOMAS
摘要:The invention relates to a method for the microbial production of metabolic products, polynucleotides from coryne-form bacteria and use thereof. According to the invention, by means of said method and polynucleotides it is possible to influence the synthesis of ATP in a controlled manner and also to control the synthesis of metabolic products. The invention relates to genes from Corynebacterium glutamicum coding for cytochrome aa 3 oxidase and the cytochrome bc 1 complex. The monocistronic ctaD gene codes for a 65 kDa protein, the primary structure of which displays all the typical properties of the sub-unit I of cytochrome aa 3 oxidase. The genes which code for the sub-unit III of the cytochrome aa 3 (ctaE) and the three characteristic sub-units of the cytochrome bc 1 complex (qcrABC) are arranged in a group with the sequence ctaE-qcrCAB. An analysis of the derived primary structure shows a sequence with unusual properties: (i) cytochrome C 1 (QcrC, 30 kDa) contains two Cys-X—X-Cys-His groups for the covalent bonding of haeme, which means that said protein is a di-haeme cytochrome of the c type; (ii) the “Rieskeâ€? iron-sulphur protein (QcrA, 45 kDa) presumably contains three trans-membrane helices in the N-terminal region; (iii) cytochromeb (QcrB, 60 kDa) contains a C-terminal extension of 120 amino acids, along with the conserved region with 8 trans-membrane helices, presumably localised in the cytoplasma. The electron transfer from the cytochrome bc 1 complex to the cytochrome aa 3 terminal oxidase does not involve additional ctochrome c.

专利号:US-2024254395-A1
优先权日:2021-06-02
标题 :Pyrolysis of polyurethane compound-containing material in order to recover raw materials
发明人：EIDEN STEFANIE; BELLINGHAUSEN RAINER; WOLF AUREL; HAHN CHRISTIAN; LODDENKEMPER TIM; JENDRZOK CAROLA
权利人:COVESTRO DEUTSCHLAND AG
摘要:The invention relates to a process according to claim 1 and pyrolysis devices used therein for the pyrolysis of pyrolysis stock comprising polyurethane-containing material, allowing carrying out pyrolysis on an industrial scale. According to the invention, even with higher amounts of pyrolysis stock an amount of pyrolysis product is obtained that contains cleavage products which can be reused for the synthesis of polyurethane-containing material.

专利号:US-2024352216-A1
优先权日:2021-08-20
标 题:Pyrolysis of a polymeric polyurethane compound in order to recover raw materials
发明人：EIDEN STEFANIE; BELLINGHAUSEN RAINER; WOLF AUREL; ALBACH ROLF
权利人:COVESTRO DEUTSCHLAND AG
摘要:The invention relates to a method according to claim 1 for the commercial implementation of a pyrolysis, and to pyrolysis devices for the pyrolysis of pyrolysis stock used in this method. The pyrolysis stock contains a polymeric compound having at least one structural polyurethane unit of the formula (I), wherein Q is a hydrocarbon group with 2 to 8 carbon atoms, preferably 3 to 8 carbon atoms, and n represents a number from 2 to 4, most preferably 2, and -* represents a covalent bond to the polymer backbone. The method and the pyrolysis device according to the invention allow, even with higher compounds of pyrolysis stock an amount of pyrolysis product to be obtained that contains cleavage products which can be reused for the synthesis of polyurethane-containing material.