CAS: 90213-66-4; 2,4-Dichloro-7H-Pyrrolo[2,3-D]Pyrimidine

上下游产品

CAS号39929-79-8 2,4-二羟基吡咯[2,3-d]嘧啶 | CAS号84955-31-7 2-氨基-4-氯吡咯并[2,3-d]嘧啶 | CAS号56473-10-0 pyrophosphoryl ... | CAS号7355-55-7 2-氨基-4-羟基吡咯并[2,... | CAS号52133-67-2 2-氰基-4,4-二乙氧基丁酸乙酯 | CAS号1053228-29-7 2,4-二氯-5-氟-7H-吡... | CAS号1053228-28-6 2,4,5-三氯-7H-吡咯[... | CAS号335654-06-3 (Z)-1-乙氧基-2-三丁基... | CAS号60129-59-1 7-Deaza-2'-脱氧腺苷 | CAS号934524-10-4 2,4-二氯-7-甲苯磺酰-7... | CAS号104291-17-0 7-DEAZA-4-氯-2'-脱氧鸟苷 | CAS号135-70-6 对四联苯 | CAS号1202885-72-0 2-Chloro-4-(mor... | CAS号1131992-22-7 7-(苯磺酰基)-2,4-二氯...

6-氨基-5-(2,2-二乙氧基乙基)-2,4(1H,3H)-嘧啶二酮置于苯膦酰二氯,盐酸,水体系中,化学反应 3.5H,反应生成 2,4-二氯-7H吡咯[2,3-D]嘧啶
参考文献:Wo2007/104944
标题:Wo2007/104944

专利信息

专利号:US-8309716-B2
优先权日:2005-07-29
标题 :Pyrrolo[2,3-d]pyrimidine derivatives: their intermediates and synthesis
发明人：RUGGERI SALLY GUT; HAWKINS JOEL M; MAKOWSKI TERESA M; RUTHERFORD JENNIFER L; URBAN FRANK J
权利人:RUGGERI SALLY GUT; HAWKINS JOEL M; MAKOWSKI TERESA M; RUTHERFORD JENNIFER L; URBAN FRANK J; PFIZER
摘要:This invention relates to methods and intermediates useful for the synthesis of pyrrolo[2,3-d]pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin-1-yl)-3-oxo-propionitrile and its corresponding citrate salt are disclosed.

专利号:US-9828380-B2
优先权日:2015-04-10
标题 :Efficient method for the preparation of tofacitinib citrate
发明人：BONANOMI JACOPO; DEFIORE STELLA; NOVO BARBARA
权利人:OLON SPA
摘要:Disclosed is a novel process for the synthesis of tofacitinib citrate on an industrial scale with high yields and purity starting with cis-(1-benzyl-4-methyl-piperidin-3-yl)methylamine bis-hydrochloride racemate (intermediate VIII), which comprises:n 1. Condensation between intermediates VII and VIII to give intermediate VI 2. Hydrogenation of intermediate VI to give intermediate V 3. Resolution of intermediate V to give intermediate IV with enantiomeric purity >99% 4. Release of intermediate IV in a basic medium to give intermediate III 5. N-acylation reaction of intermediate III to give II (tofacitinib) 6. Salification of intermediate II to give tofacitinib monocitrate (I)

专利号:WO-2025003177-A1
优先权日:2023-06-27
标题:Benzyl (3-(methyl(7h-pyrrolo[2,3-d]pyrimidin-4yl)amino)cyclobutyl) carbamate or a salt thereof, method for the preparation thereof, and use thereof in the synthesis of abrocitinib

专利号:CN-109608468-A
优先权日:2018-12-29
标 题 :A kind of tofacitinib citrate impurity and its synthesis method and use

专利号:US-12233062-B2
优先权日:2018-09-26
标 题 :Heterocyclic derivatives useful as SHP2 inhibitors
发明人：HAN HUIFENG; GAO PANLIANG; MA CUNBO; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

专利号:AR-056004-A1
优先权日:2005-07-29
标 题 :PIRROLO DERIVATIVES [2, 3 -D] PYRIMIDINE, SYNTHESIS METHODS OF THE SAME AND ITS PREPARATION INTERMEDIARIES