CAS: 118399-22-7; (2Z,5R,6S,9S,12S,13S,16R)-9-[3-(Diaminomethylideneamino)Propyl]-2-Ethylidene-12-[(1E,3E,5S,6S)-6-Methoxy-3,5-Dimethyl-7-Phenylhepta-1,3-Dienyl]-1,6,13-Trimethyl-3,7,10,14,19-Pentaoxo-1,4,8,11,15-Pentazacyclononadecane-5,16-Dicarboxylic Acid

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CAS号1187315-06-5 Nod-AM2 | CAS号1187315-08-7 Nod-PM2

Nod-Am2置于pig Liver Esterase体系中,化学反应生成节球毒素
参考文献:Acyloxymethyl Esterification Of Nodularin-R And Microcystin-La Produces Inactive Protoxins That Become Reactivated And Produce Apoptosis Inside Intact Cells
标题:Acyloxymethyl Esterification Of Nodularin-R And Microcystin-La Produces Inactive Protoxins That Become Reactivated And Produce Apoptosis Inside Intact Cells
摘要:We Report The Esterification Of The Carboxyl Groups Of The Cyclic Peptide Toxins Nodularin-R. And Microcystin-La To Produce Stable Diacetoxymethyl And Dipropionyloxymethyl Ester Derivatives. The Derivatives Had No Activity But Were Reactivated Upon Esterase Treatment. When Injected Into Cells,The Acyloxymethyl Moieties Were Cleaved Off And Apoptosis Induced. Linking The Acyloxymethyl-Ester Moiety Of These Potent Toxins To Carriers Destined For Endocytosis Paves The Way For Selective Apoptosis Induction In Target (E.G.,Cancer) Cells.
Doi:10.1021/jm900502E