CAS: 1600-44-8; Tetrahydrothiophene 1-Oxide

该化合物是一个含硫的环环化合物,其特点是五人环形结构,具有一个氯酮功能组.分子对有机合成和制药研究感兴趣,因为它具有多功能中间体的潜力.硫柳木环和碳基组的存在允许多种反应性,有利于在开发基于硫的离心,催化剂或生物活性分子中应用.其结构特征还可能促进立体化学和环状转化的研究.该化合物的稳定性和合成可及性使得它成为医学化学和材料科学探索性研究的实用选择,而经常需要定制的硫化循环.

结构式图片

相似化合物

126-33-0 50578-18-2 17115-51-4

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CAS号110-01-0 四氢噻吩(THT) | CAS号420-04-2 氰胺 | CAS号50578-18-2 1-亚氨基-1-氧代硫杂环戊烷 | CAS号100-68-5 茴香硫醚 | CAS号126-33-0 环丁砜 | CAS号66021-66-7 4-methyl-N-oxob... | CAS号25862-08-2 benzylseleninyl... | CAS号934-72-5 甲基对甲苯亚砜 | CAS号70284-20-7 potassium N-bro... | CAS号106-98-9 正丁烯 | CAS号187737-37-7 propene | CAS号54509-73-8 ethene | CAS号287-23-0 環丁烷 | CAS号75-19-4 环丙烷 | CAS号106-99-0 丁二烯 | CAS号129623-68-3 2-dodecylthiola... | CAS号1608-66-8 acetic acid,thi... | CAS号15436-35-8 Thiophene,1,1,2... | CAS号126-33-0 环丁砜

合成工艺路线路线简述

    四氢噻吩置于双氧水体系中,用 Neat (No Solvent) 用作溶剂,化学反应 0.33H,以98%的收率获得四甲基亚砜
    参考文献:Feso3磁性纳米颗粒上负载的三氨基甲烷-钴配合物,是硫化物氧化和cs偶联反应的有效可回收纳米催化剂
    标题:Feso3磁性纳米颗粒上负载的三氨基甲烷-钴配合物,是硫化物氧化和cs偶联反应的有效可回收纳米催化剂
    摘要:在这项工作中,三氨基甲烷-钴络合物固定在fe 3 O 4的表面上通过简单且廉价的程序成功制备了磁性纳米颗粒.所制备的纳米催化剂被认为是在绿色条件下用于氧化和合成硫化物的坚固,清洁的纳米反应器催化剂.这种环保型非均相催化剂的特征在于傅立叶变换红外光谱,X射线衍射法,能量色散x射线光谱法,电感耦合等离子体原子发射光谱法,热重分析,振动样品磁力分析法,X射线作图,扫描电子显微镜和透射电子显微镜技术.使用绿色介质,易于分离和后处理,纳米催化剂的优异可重复使用性以及较短的反应时间是该方法的一些突出优点.
    Doi:10.1002/aoc.5260

    海关参考信息

    专利信息


    专利号:US-4918222-A
    优先权日:1984-07-27
    标 题 :Process for synthesis of N-acetylglycine
    发明人:LIN JIANG-JEN; KNIFTON JOHN F; YEAKEY ERNEST L
    权利人:TEXACO INC
    摘要:An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.

    专利号:US-4782146-A
    优先权日:1986-07-29
    标题 :Process for the synthesis of penems
    发明人:BRIGHTY KATHERINE E
    权利人:PFIZER
    摘要:A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.

    专利号:US-11794179-B2
    优先权日:2016-08-24
    标 题 :Synthesis and characterization of metathesis catalysts
    发明人:JOHNS ADAM M
    权利人:UMICORE AG & CO KG
    摘要:This invention relates generally to olefin metathesis catalysts, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, and the use of such compounds in the metathesis of olefins and in the synthesis of related olefin metathesis catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and in industrial applications such as oil and gas, fine chemicals and pharmaceuticals.

    专利号:US-7189864-B2
    优先权日:1990-11-19
    标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
    权利人:SEARLE & CO
    摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

    专利号:US-6022996-A
    优先权日:1990-11-19
    标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
    发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
    权利人:SEARLE & CO
    摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

    专利号:EP-0641333-B1
    优先权日:1992-05-20
    标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
    发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
    权利人:SEARLE & CO; MONSANTO CO
    摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.
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    主要参考文献

    [参考文献]: G G Balavoine, Et Al. Catalysis Of Peroxynitrite Reactions By Manganese And Iron Porphyrins. Nitric Oxide. 1997;1(6):507-21.
    [参考文献]: R A Page, Et Al. The Importance Of Alcohol Dehydrogenase In Regulation Of Ethanol Metabolism In Rat Liver Cells. Biochem J. 1991 Sep 15;278 ( Pt 3)(Pt 3):659-65.
    [参考文献]: V K Chadha, Et Al. Inhibition By Carboxamides And Sulfoxides Of Liver Alcohol Dehydrogenase And Ethanol Metabolism. J Med Chem. 1983 Jun;26(6):916-22.

    合成参考文献


    摘要:Wu, X.-F., Science of Synthesis Knowledge Updates, (2014) 1, 328.
    摘要:Kantak, A.; DeBoef, B., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 616.
    摘要:Sokolovs, I.; Suna, E., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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