专利号:US-4918222-A 优先权日:1984-07-27 标 题 :Process for synthesis of N-acetylglycine 发明人:LIN JIANG-JEN; KNIFTON JOHN F; YEAKEY ERNEST L 权利人:TEXACO INC 摘要:An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.
专利号:US-4782146-A 优先权日:1986-07-29 标题 :Process for the synthesis of penems 发明人:BRIGHTY KATHERINE E 权利人:PFIZER 摘要:A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.
专利号:US-11794179-B2 优先权日:2016-08-24 标 题 :Synthesis and characterization of metathesis catalysts 发明人:JOHNS ADAM M 权利人:UMICORE AG & CO KG 摘要:This invention relates generally to olefin metathesis catalysts, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, and the use of such compounds in the metathesis of olefins and in the synthesis of related olefin metathesis catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and in industrial applications such as oil and gas, fine chemicals and pharmaceuticals.
专利号:US-7189864-B2 优先权日:1990-11-19 标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors 发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P 权利人:SEARLE & CO 摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
专利号:US-6022996-A 优先权日:1990-11-19 标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors 发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P 权利人:SEARLE & CO 摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
专利号:EP-0641333-B1 优先权日:1992-05-20 标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors 发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P 权利人:SEARLE & CO; MONSANTO CO 摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.
[参考文献]: G G Balavoine, Et Al. Catalysis Of Peroxynitrite Reactions By Manganese And Iron Porphyrins. Nitric Oxide. 1997;1(6):507-21. [参考文献]: R A Page, Et Al. The Importance Of Alcohol Dehydrogenase In Regulation Of Ethanol Metabolism In Rat Liver Cells. Biochem J. 1991 Sep 15;278 ( Pt 3)(Pt 3):659-65. [参考文献]: V K Chadha, Et Al. Inhibition By Carboxamides And Sulfoxides Of Liver Alcohol Dehydrogenase And Ethanol Metabolism. J Med Chem. 1983 Jun;26(6):916-22.
合成参考文献
摘要:Wu, X.-F., Science of Synthesis Knowledge Updates, (2014) 1, 328. 摘要:Kantak, A.; DeBoef, B., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 616. 摘要:Sokolovs, I.; Suna, E., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .