CAS: 2268-16-8; 2,4,5-Trifluorophenol

上下游产品

CAS号367-34-0 2,4,5-三氟苯胺 | CAS号327-54-8 1,2,4,5-四氟苯 | CAS号2267-67-6 3-(2,4,5-triflu...

1,2,4,5-四氟苯置于氢氧化钾体系中,用 二甲基亚砜 用作溶剂,化学反应 4.0H,反应生成2,4,5-三氟苯酚
参考文献:Allen,Kim J.; Bolton,Roger; Williams,Gareth H.,Journal Of The Chemical Society. Perkin Transactions Ii,1983,P. 691-696
标题:Allen,Kim J.; Bolton,Roger; Williams,Gareth H.,Journal Of The Chemical Society. Perkin Transactions Ii,1983,P. 691-696

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.