CAS: 2650-64-8; N-Carbobenzyloxy-L-Glutamine

相似化合物

13139-52-1 50516-14-8 102747-84-2

上下游产品

CAS号56-85-9 L-谷氨酰胺 | CAS号501-53-1 氯甲酸苄酯 | CAS号250296-57-2 N-Benzyloxycarb... | CAS号75819-24-8 3-benzyloxycarb... | CAS号4124-76-9 benzyl N-(2,6-d... | CAS号35726-62-6 N-Cbz-L-谷氨酸-5-乙酯 | CAS号4510-09-2 N-benzyloxycarb... | CAS号38596-35-9 dicyclohexylami... | CAS号100-51-6 苯甲醇 | CAS号3077-51-8 (S)-2-氨基-5-甲氧基-... | CAS号34078-85-8 苄氧羰基-谷氨酰胺酰-琥珀酰亚胺 | CAS号22785-43-9 (S)-3-N-Cbz-氨基-... | CAS号191732-76-0 5-氨基-2-(2,6-二氧代... | CAS号19171-18-7 4-硝基沙利度胺 | CAS号28252-49-5 N-(二(4-甲氧基苯基)甲基... | CAS号827026-45-9 3-(4-硝基-1-氧代-1,... | CAS号7763-16-8 Z-谷氨酰胺对硝基苯酯 | CAS号6610-42-0 Z-谷氨酰甘氨酸 | CAS号62234-40-6 N-alpha-苄氧羰基-L-... | CAS号56-85-9 L-谷氨酰胺

L-谷氨酰胺置于二环己胺,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 6.0H,以166.2 G的收率获得n-苄氧羰基-L-谷氨酰胺
参考文献:一种(S)-1-(苄氧羰基)-5-氧代吡咯烷-2-甲酸的制备方法
标题:一种(S)-1-(苄氧羰基)-5-氧代吡咯烷-2-甲酸的制备方法
摘要:本发明公开了一种(S)‑1‑(苄氧羰基)‑5‑氧代吡咯烷‑2‑甲酸的制备方法,主要解决原工艺中的复杂性,周期长,成本高,纯度低等技术问题,本发明具体包括以下步骤:第一步,由l‑谷氨酸和苄氧羰基供体制备得n‑苄氧羰基‑l‑谷氨酸,第二步,将n‑苄氧羰基‑l‑谷氨酸进行分子内缩合环化制得n‑苄氧羰基‑l‑谷氨酸粗品;第三步,将n‑苄氧羰基‑l‑谷氨酸粗品和有机胺碱混合,利用产品在溶剂中的溶解度制得其有机胺盐式,第四将n‑苄氧羰基‑l‑谷氨酸有机胺盐式脱盐后制备得(S)‑1‑(苄氧羰基)‑5‑氧代吡咯烷‑2‑甲酸.本发明制备得到高纯度的产品,收率和品质都得到了较大的提高.

专利信息

专利号:WO-2010103857-A1
优先权日:2009-03-12
标 题 :Method for solid-phase synthesis of glycopeptide using silicon-containing protecting group and synthesis device
发明人：NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
权利人:UNIV HOKKAIDO NAT UNIV CORP; NISHIMURA SHIN-ICHIRO; SHIMAWAKI KEN
摘要:Disclosed are a novel method for the synthesis of a glycopeptide by which glycopeptides of various types can be deprotected and excised from a resin, each under weakly acidic to weakly basic conditions, without causing the problems of the epimerization of an amino acid at the a-position and the ß-elimination of a sugar residue; a synthesis device therefor; and a synthesis intermediate to be used in synthesizing a glycopeptide. Specifically disclosed are a method for the solid-phase synthesis of a glycopeptide which comprises a step for obtaining a glycopeptide derivative wherein the N-terminus is protected, the C-terminus is immobilized to a solid phase via a silicon linker, and a reactive group carried by a sugar residue and a reactive group carried by an amino acid side chain constituting a peptide are protected by silicon-containing groups, and a step for obtaining the glycopeptide by deprotecting said glycopeptide derivative and releasing the same from the solid phase by treating the glycopeptide derivative with an agent for removing the silicon-containing groups and the silicon linker; a synthesis intermediate to be used in the step for obtaining the glycopeptide derivative in the aforesaid method; and a device for the solid-phase synthesis of a glycopeptide.

专利号:US-4704450-A
优先权日:1983-02-21
标 题 :Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4581168-A
优先权日:1983-02-21
标题:Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4797469-A
优先权日:1984-07-10
标 题:Synthesis of hGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF, (1) on the one hand, the following fragments: -H-Ala-Arg-Ala-Arg-Leu-NH2 called Fragment A hGRF (40-44) or - alaninamide (40) -H-Gln-Glu-Arg-Gly-OH called Fragment B'1 hGRF (36-39) -H-Glu-Ser-Asn-OH called Fragment B'2 hGRF (33-35) -H-Ser-Arg-Gln-Gln-Gly-OH called Fragment C hGRF (28-32) -H-Leu-Gln-Asp-Ile-Met-OH called Fragment D' hGRF (23-27) -H-Arg-Lys-Leu-OH called Fragment E'1 hGRF (20-22) - to obtain the peptide K1 [(hGRF (20-44)] on the corresponding peptide having the sequence (20-40) and (2) on the other hand, the following fragments: -H-Gln-Leu-Ser-Ala called Fragment F1 hGRF (16-19) -H-Tyr-Arg-Lys-Val-Leu-Gly OH called Fragment G1 hGRF (10-15) -H-Ile-Phe-Thr-Asn-Ser-OH called Fragment H1 hGRF (5-9) - to obtain the peptide J [hGRF (5-19)] and thereafter to couple together the peptides J and K1 in order to form the peptide having the sequence hGRF (5-44) or hGRF (5-40) and finally to couple the resulting peptide with the peptide H-Tyr-Ala-Asp-Ala-OH, called fragment I hGRF (1-4).

专利号:US-5455363-A
优先权日:1991-10-11
标题 :Amino acid derivatives for peptide synthesis
发明人：GOSTELI JACQUES; SAX BEAT; DICK FRITZ; TANNER RUDOLF
摘要:Compounds of formula I are described, I wherein n is equal to one or two, R1 stands for hydrogen or an amino protecting group, R2 represents hydrogen or a carboxyl protecting group and R3 4-methyltriphenylmethyl, 4,4'-dimethyltriphenylmethyl, 4,4',4''-trimethyltriphenylmethyl. Furthermore described are compounds of formula I which are reactive and suitable for coupling reactions and are derived from I with R2=H by activation of the carboxyl group. The compounds mentioned above can be used as starting materials for the synthesis of peptides. They are more suitable than analogous compounds of formula I, wherein R3 represents hydrogen or a carbamoyl protecting group used hitherto.

专利号:US-3795666-A
优先权日:1969-08-01
标 题 :Method of synthesizing peptides in the presence of a carbodiimide and of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine
发明人：KONIG W; GEIGER R; WOLF E
权利人:HOECHST AG
摘要:IMPROVED SYNTHESIS OF PEPTIDES BY THE CARBODIIMIDE METHOD IN WHICH AN AMINO-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE CARBOXY GROUP IS CONDENSED WITH A CARBOXY-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE AMINO IN THE PRESENCE OF 3-HYDROXY-4-OXO3,4-DIHYDRO-1,2,3-BENZOTRIAZINE AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.