3-甲氧基苯酚置于phenylphosphorus Tetrachloride体系中,用80%的收率获得3-氯苯甲醚 参考文献:Preparation Of Aryl Chlorides From Phenols 标题:Preparation Of Aryl Chlorides From Phenols 摘要: Doi:10.1021/jo00297A087
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-4565896-A 优先权日:1984-10-22 标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas 发明人:KNIFTON JOHN F; DURANLEAU ROGER G 权利人:TEXACO INC 摘要:This invention relates to the manufacture of ethylene glcyol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus formaldehyde in the presence of a homogeneous liquid catalyst containing an effective amount of cobalt-containing compound and a silicon or germanium-containing promoter and a solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi wherein said ethylene glycol product separates as a separate liquid phase from the solvent.
专利号:US-4568780-A 优先权日:1984-10-22 标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas plus 1,3-dioxolane 发明人:KNIFTON JOHN F 权利人:TEXACO INC 摘要:This invention relates to the manufacture of ethylene glycol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus 1,3-dioxolane in the presence of a homogenous liquid catalyst containing an effective amount of cobalt-containing compound and a silane or germane-containing promoter dispersed in a hydrocarbon solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi, where the particular solvents used allow the desired product to be separated from the reaction mixture by phase separation.
专利号:US-8114993-B2 优先权日:2007-02-06 标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization 发明人:DAUGULIS OLAFS; CHIONG HENDRICH 权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM 摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.
专利号:US-4453012-A 优先权日:1982-04-22 标 题 :Process for the preparation of phenyl ketones 发明人:DESBOIS MICHEL 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.
专利号:US-4454350-A 优先权日:1982-01-21 标题:Process for the acylation of halo- or trihalomethylbenzenes 发明人:DESBOIS MICHEL 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the acylation of halo- or trihalomethylbenzenes, wherein a halo- or trihalomethylbenzene is reacted with a carboxylic acid, a precursor or a derivative thereof in the presence of boron trifluoride in an amount such that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having a phytosanitary (e.g., herbicidal) or pharmaceutical activity.
[参考文献]: Roberto Sanz, Et Al. Regioselective Synthesis Of 4- And 7-Alkoxyindoles From 2,3-Dihalophenols: Application To The Preparation Of Indole Inhibitors Of Phospholipase A2. J Org Chem. 2007 Jul 6;72(14):5113-8.
合成参考文献
摘要:Delvos, L. B.; Oestreich, M., Science of Synthesis Knowledge Updates, (2017) 1, 158. 摘要:Song, Z.; Takahashi, T., Science of Synthesis Knowledge Updates, (2013) 1, 85. 摘要:Molander, G. A.; Beaumard, F., Science of Synthesis Knowledge Updates, (2013) 3, 113. 摘要:Collings, J. C., Science of Synthesis Knowledge Updates, (2013) 4, 306. 摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 227.