合成目标产物 4-Acetoxyindole 主要起始原料 4-Hydroxyindole And Acetic Anhydride
(文献来源)合成步骤主要原料 4-Hydroxyindole 和 Acetic Anhydride
Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇,铁粉,溶剂黄146体系中,化学反应生成 4-乙酰氧基吲哚 参考文献:Beer Et Al.,Journal Of The Chemical Society,1948,P. 1605,1608 标题:Beer Et Al.,Journal Of The Chemical Society,1948,P. 1605,1608
专利号:WO-2024062080-A1 优先权日:2022-09-21 标题:Improved synthesis of psilocybin derivatives 发明人:HAMMES CHRISTIAN; STÖCKLI STEFAN 权利人:CARBOGEN AMCIS AG; AAMANYA AG 摘要:The present invention relates to an improved synthesis of psilocybin and alkyl- derivatives of psilocybin such as ethocybin (4-phosphoryloxy-N,N-diethyltryptamine, also known as phosphoryloxy-DET, PO-DET or CEY-39) and furthermore, relates to intermediates useful in the synthesis of these compounds.
专利号:US-5262546-A 优先权日:1992-11-17 标 题:Process for the preparation of 5,6-diacetoxyindole 发明人:PAN YUH-GOO; LIM MU-ILL 权利人:CLAIROL INC 摘要:An indole of the formula ##STR1## wherein R 5 and R 6 are acetoxy or hydrogen, at least one of R 5 and R 6 being acetoxy, is prepared, in good yield, in a one pot synthesis, without extraction, recrystallization or isolation of intermediate reaction product; A compound of the formula ##STR2## wherein R 1 and R 2 are benzyloxy or hydrogen, provided that at least one of R 1 and R 2 is benzyloxy, is subjected to reductive cyclization followed by acetylation of the resultant reaction product.
专利号:CN-117597329-A 优先权日:2021-05-05 标题:Method for the catalytic synthesis of tryptamine and precursors thereof
专利号:EP-4590682-A1 优先权日:2022-09-21 标题 :Improved synthesis of psilocybin derivatives
参考文献:10.1055/s-0039-1691565 摘要:Kargbo RB, Sherwood AM, Meisenheimer P, Tarpley G. An Improved, Practical, and Scalable Five-Step Synthesis of Psilocybin. Synthesis. 2020 Jan 08;52(05):688–94. doi: 10.1055/s-0039-1691565.