- ⚠️《2026年兴奋剂目录》
- 英文名称Methandrostenolone
- 中文名称美雄酮
- IUPAC名称(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
- 其它别名1-Dehydro-17a-methyltestosterone; 17a-methyl-17b-hydroxy-1,4-androstadien-3-one; 17beta-Hydroxy-17-methylandrosta-1,4-dien-3-one
- CAS编号72-63-9
- MFCD编号:MFCD00003650
- EINECS号:200-787-2
- FDA UNII编号:COZ1R7EOCC
- 分子式:C20H28O2
- 分子量:300.44
- 产品CID: 1711792
- 产品分类原料药 → 激素及调节内分泌功能类药 → 雄激素及同化激素类药
- 相似结构搜索
- 产品信息参考
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- InChIKey: XWALNWXLMVGSFR-HLXURNFRSA-N
- InChI=1/C20H28O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h6,9,12,15-17,22H,4-5,7-8,10-11H2,1-3H3/t15-,16+,17+,…
- 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0
上下游产品
methylene chloride androsta-1,4-diene-3,17-dione 17-methyltestosterone Androsta-1,4-diene-3,17-dione17-methyltestosterone (14)-trien-3-one17,17-dimethyl-18-norandrosta-1,4,13(14)-trien-3-one 1.5-androstadien-3-on17β-Hydroxy-17α-methyl-Δ1.5-androstadien-3-on 17α-methyl-4-androstene-3β,17β-diol 合成工艺路线路线简述
- 合成目标产物 Metandienone 主要起始原料 Methyl Bromide And Androsta-1,4-Diene-3,17-Dione
- (文献来源)合成步骤主要原料 Methyl Bromide 和 Androsta-1,4-Diene-3,17-Dione
17-甲睾酮置于selenium(Iv) Oxide体系中,化学反应生成 美雄酮
参考文献:Gewinnung Von 1; 4-Bisdehydro-3-Oxo-Steroiden.übersteroide,139.
标题:Gewinnung Von 1; 4-Bisdehydro-3-Oxo-Steroiden.übersteroide,139.
摘要:描述了一种方法,该方法使得能够仅在一个化学步骤中从环a中饱和的3-氧-甾族化合物或从αβ-单不饱和的3-酮中特别生产1,4-双脱氢-3-氧-甾族化合物.脱氢剂是二氧化硒,溶剂是叔醇,优选含有一些酸.
DOI:10.1002/hlca.19560390314
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示:海关信息按照顺序优先匹配,如需确认的海关信息,请参考相关资料。
- 详情请参考:📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人:PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.
专利号:US-2014274978-A1
优先权日:2013-03-15
标题 :Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals
发明人:FASCIOLA ANDRE ARMEL
权利人:FASCIOLA ANDRE ARMEL
摘要:The present invention utilizes phytosterol, phytoecdysteroid, sapogenin, triterpene, terpene, spirostane, spirostene and androstene derivative compounds to provide a wide variety of utilities to humans and other animals. The compounds and methods provide numerous and wide-ranging benefits including biochemical and constructive metabolic benefits including increases in protein synthesis and synthesis efficiency, ergogenic, adaptogenic, cosmetic and medicinal skin agents and veterinary utilities. The compounds provide agents that increase physical endurance and work output, act as a general tonic for increasing health and vigor, increase sleep time and sleep efficiency and act as rejuvenating agents to reverse the effects of fatigue and stress. Novel utilities for pet, farm, zoo and companion animals are also provided.
专利号:US-6333317-B1
优先权日:1997-03-28
标 题:Regulation of amyloid precursor protein (APP) expression by administration of an estrogenic compound
发明人:LEE ROBERT K K; WURTMAN RICHARD J
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:It has been discovered that lipophilic hormones that interact with cytosolic or nuclear receptors regulate APP expression and synthesis, through modification of APP mRNA stability and/or regulation of APP gene transcription and translation activities. These studies demonstrate that the treatment of brain cells with estrone or 17β-estradiol results in a reduction in the level of APP holoprotein expression, without a concomitant change in the total level of cell protein. The reduction in the level of APP holoprotein caused by estrone or 17β-estradiol is also expected to reduce the production of neurotoxic APP fragments. In as much as estrogen deficiency in postmenopausal women is associated with a higher incidence of Alzheimer's disease, this discovery opens the possibility that estrogen therapy may prevent some of the neurodegenerative and cognitive changes associated with Alzheimer's disease, aging and other disease conditions associated with such neurodegenerative and cognitive decline.
专利号:CN-102286062-A
优先权日:2011-06-15
标 题 :Synthesis of 16α, 17α-epoxy-4-pregnene-3,20-dione
专利号:US-9700589-B2
优先权日:2015-02-03
标题:Compositions and methods for improved muscle metabolism
发明人:BILY ANTOINE CHARLES; MEYER MARJOLAINE; CHEVALIER KARL; Laurençon Lise; FEUILLERE NICOLAS; ROLLER MARC; BIRTIC SIMONA
权利人:NATUREX SA
摘要:A composition for improving muscle metabolism in a subject and methods for manufacturing and using same. Embodiments include compositions having an extract of Rhaponticum and an extract of Rhodiola . An extract of Rhaponticum may include amounts of ecdysterones including 20-hydroxyecdysone. An extract of Rhodiola my include salidrosides and rosavins, including rosavin. Suitable ingestion dosages of the composition may be operable to increase protein synthesis and reduce protein proteolysis in a subject.
专利号:US-2025281509-A1
优先权日:2021-04-26
标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer
发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER
权利人:UNIV JOHNS HOPKINS
摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.