CAS: 76823-03-5; 3',6'-Dihydroxy-3-Oxo-3H-Spiro[isobenzofuran-1,9'-Xanthene]-5-Carboxylic Acid

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CAS号108-46-3 间苯二酚 | CAS号552-30-7 偏苯三酸酐 | CAS号79955-27-4 5-羧基荧光素二乙酸酯 | CAS号79955-27-4 5-羧基荧光素二乙酸酯

5-羧基荧光素二乙酸酯置于反式-4-乙酰氧基肉桂酸,水体系中,用 二甲基亚砜 作为反应溶剂,化学反应生成 5-羧基荧光素
参考文献:An Enzymatic Chemical Amplifier Based On Mechanized Nanoparticles
标题:An Enzymatic Chemical Amplifier Based On Mechanized Nanoparticles
摘要:A Chemical Amplifier Was Constructed Based On Enzyme-Encapsulated Mesoporous Silica Nanoparticles. By Employing A Supramolecular Nanogate Assembly That Is Capable Of Controlling The Access To The Encapsulated Enzyme,Selectivity Toward Substrate Sizes Is Enabled. When An Analyte Molecule Actuates The Mechanical Nanogate And Exposes The Enzymes,A Catalytic Production Of Fluorescent Molecules Is Initiated. This Study Demonstrates A New Concept Of Self-Amplification Of A Chemical Sensing Process And Can Potentially Increase The Detection Sensitivity.
DOI:10.1021/ja4066317

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:WO-2012088402-A1
优先权日:2010-12-22
标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain
发明人：BOHN LAURA M; MICALIZIO GLENN C
权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C
摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.

专利号:US-10047122-B2
优先权日:2013-03-14
标 题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：QIAN WENJIAN; PARK JUNG EUN; LAI CHRISTOPHER C; KELLEY JAMES A; LEE KYUNG S; BURKE JR TERRENCE R
权利人:THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.