CAS: 80789-69-1; 1-(4-Chlorophenyl)Cyclopentanecarboxylic Acid

上下游产品

CAS号64399-26-4 1-(4-氯苯基)环戊烷-1-腈 | CAS号140-53-4 对氯苯乙腈 | CAS号71501-44-5 1-(4-氯苯基)-1-环戊羰酰氯 | CAS号80866-79-1 1-(p-chlorophen...

对氯苯乙腈置于potassium Hydroxide,Sodium Hydroxide体系中,用 乙二醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 13.5H,反应生成 1-(4-氯苯基)-1-环戊烷甲酸
参考文献:Synthesis And Biological Activity Of Arylcyclopentane-1-Carboxylic Acids Aminoesters
标题:Synthesis And Biological Activity Of Arylcyclopentane-1-Carboxylic Acids Aminoesters
摘要:1-Arylcyclopentane-1-Carboxylic Acids Were Synthesized By Alkaline Hydrolysis Of The Corresponding Nitriles. Reactions Of The Acid Chlorides With N,N-Dialkylaminoalkyl-And Hetarylalkylalkanols Provided New Aminoester Derivatives Of 1-Arylcyclopentane-1-Carboxylic Acids. Sympatholytic And Adrenolytic Activity Of The Obtained Amino Esters Hydrochlorides Was Studied.
DOI:10.1134/s107036321905027X

专利信息

专利号:US-7511141-B2
优先权日:2001-03-02
标题 :Piperidine-piperazine ligands for neurotransmitter receptors
发明人：PERSONS PAUL E; RADEKE HEIKE
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to piperidine-piperazine compounds. A second aspect of the present invention relates to the use of the piperidine-piperazine compounds as ligands for various mammalian cellular receptors or transporters or both, including dopamine, serotonin or norepinephrine receptors or transporters, any combination of them, or all of them. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the piperidine-piperazine compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine receptors or transporters or both.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.