CAS: 128363-76-8; Borane-Di(Tert-Butyl)Phosphine Complex

该化合物是一个协调化合物,其特点是和磷;由于有中心,该复合体通常具有四面形几何学,由聚丁磷离心加以协调;磷-丁基离心管组会助长阻塞,影响该复合体的再活动性和稳定性;其特征一般是,它具有作为刘易斯酸的功能,因为有电脱精的原生蛋白原子,使其在各种有机合成反应中有用,特别是在水合过程中.该复合体通常在惰性大气中处理,以防止降解或与湿度发生反应.其在有机溶剂中的溶解性可以用于合成化学.此外,磷离心能会增强该物质中心的电子特性,使它成为形成碳质结质中的一种有价值的再试剂.

英文名称Borane-Di(Tert-Butyl)Phosphine Complex
中文名称硼烷二-叔-丁基膦络合物
其它别名Phosphine,bis(1,1-dimethylethyl)-, boron complex; (Di-tert-butylphosphine)trihydroboron; Di-tert-butylphosphine borane
CAS编号128363-76-8
MFCD编号:MFCD03412071
EINECS号:677-700-3
分子式:C8H22BP
分子量:160.05
产品CID: 443698
产品分类化学试剂 → 有机试剂 → 硼烷

相似结构搜索
InChIKey: NFTWUNMDOWXENK-UHFFFAOYSA-N
1S/C8H19P.B/c1-7(2,3)9-8(4,5)6;/h9H,1-6H3;…
计算化学: 氢键受体数*氢键供体数0.0可旋转键数2.0

物理性质

熔点59-64 °C
沸点59-64 °C
PSA:13.59
LogP:2.078
敏感性如果遵照规格使用和储存则不会分解，未有已知危险反应避免氧化物、水分等
外观形态白色晶体
储存条件保持贮藏器密封保存、储存在阴凉、干燥环境的地方，确保工作间有良好的通风或排气装置
产品应用该化合物用于以下用途的再活性剂:用刘易斯基交换反应制备N-热环碳苯丙烷复合化合物;脱氢相对反应;对氟苯乙烯铬复合物的远距离替代反应;

MSDS等安全信息

警示词Warning
危险描述H261 (100%): In contact with water releases flammable gas [Danger Substances and mixtures which in contact with water, emit flammable gases]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
防范说明P231+P232, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P402+P404, P403+P233, P405, and P501
危险品标志F
安全声明S43
危险类别码R15
WGK Germany3

上下游产品

sodium tetrahydroborate di(tert-butyl)chlorophosphine borane-THF di-tert-butylphosphinedi(tert-butyl)((2-[(diisopropylphosphino)methyl]phenyl)methyl)phosphine-borane (1/2) di(tert-butyl)((2-([(tert-butyl)isopropylphosphino]methyl)phenyl)methyl)phosphine-borane (1/2) 1-(di-tert-butylphosphino{borane}methyl)-2-(diphenylphosphinomethyl)benzene 1-(di-tert-butylphosphino{borane}methyl)-2-(di-o-tolylphosphino{borane}methyl)benzene

合成工艺路线路线简述

专利信息

专利号:US-9035061-B2
优先权日:2010-07-13
标题:Process for preparing a biphenyl-2-ylcarbamic acid
发明人：COLSON PIERRE-JEAN
权利人:COLSON PIERRE-JEAN; THERAVANCE BIOPHARMA R & D IP LLC
摘要:The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.

专利号:WO-2022049604-A1
优先权日:2020-09-05
标题 :Process for preparing revefenacin and intermediates therof
发明人：DAS ARIJIT; SINGH MANJINDER; BHOSALE RAJESH; SAWANT ASHWINI; CHAVAN AMIT; SUKTE ANKUSH; TARATE SAGAR; THAKUR NITIN; PATIL RAVINDRA
权利人:CIPLA LTD
摘要:The present invention relates to processes and intermediates for the synthesis of Revefenacin or pharmaceutically acceptable salts thereof.

专利号:EP-1243591-A2
优先权日:2001-03-19
标题 :Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

专利号:US-2004138487-A1
优先权日:2001-03-19
标题 :Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

专利号:US-6689915-B2
优先权日:2001-03-19
标题:Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation

专利号:US-2002143214-A1
优先权日:2001-03-19
标题:Synthesis of non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation