CAS: 1320-06-5; 1-(2,5-Dimethyl-4-(2,5-Dimethylphenylazo)Phenylazo)-2-Naphthol

专利信息

专利号:US-2024209029-A1
优先权日:2021-04-21
标题:Adiponectin glycopeptides and compositions and methods of use thereof
发明人：WANG YU; LI XUECHEN; XU AIMIN; WU HONGXIANG; ZHANG YIWEI; LI YUANXIN
权利人:UNIV HONG KONG
摘要:An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.

专利号:US-2009053804-A1
优先权日:2007-07-27
标题:Methods of reducing intracellular fats from mammalian cells
发明人：RUIZ JOSEPH CHARLES
权利人:VESTA THERAPEUTICS INC
摘要:The present invention provides methods of reducing or clearing fat from mammalian cells. The method comprises culturing the cells in an environment that facilitates: 1) reduction of de novo fatty acid synthesis, 2) activation or synthesis of fatty acid oxidizing enzymes, and/or 3) export of lipids out of the cells. Cells substantially free of fatty acid are also provided in this invention.

专利号:US-2005182020-A1
优先权日:2003-11-14
标题 :Ceramide de novo synthesis-based therapeutic and prophylactic methods, and related articles of manufacture
发明人：WORGALL TILLA S; DECKELBAUM RICHARD J
摘要:Described is a method for decreasing the amount of mSREBP in a cell characterized by an elevated level of mSREBP comprising contacting the cell with an agent that specifically inhibits de novo synthesis of ceramide in the cell, thereby decreasing the amount of mSREBP in the cell. Also described are related methods and articles of manufacture.

专利号:WO-2025045059-A1
优先权日:2023-09-01
标题 :Use of anti-igf-1r antibody or antigen binding portion thereof in weight loss
发明人：LIANG XIAO; GUO SHUHUA; MA LIN; PANG LIANG
权利人:SUZHOU PRO HEAL PHARMACEUTICALS TECH CO LTD
摘要:Provided is a use of an anti-IGF-1R antibody or an antigen binding portion thereof in weight loss. The anti-IGF-1R antibody or the antigen binding portion thereof carries out weight loss by means of at least one of the following mechanisms: (1) inhibiting or blocking the binding between IGF-1R and IGF-1; (2) reducing, weakening or neutralizing the activity of IGF-1R; (3) inhibiting cell proliferation; (4) inhibiting fat synthesis and/or accumulation of cells; and (5) inhibiting collagen synthesis of cells. The anti-IGF-1R antibody or the antigen binding portion thereof can significantly inhibit the generation and accumulation of fat, effectively inhibit the formation of collagen, and has a significant effect in treatment of obesity and weight loss.

专利号:US-8754058-B2
优先权日:2009-09-29
标 题:Inhibitors of FAM3B gene, inhibitor compositions, inhibiting methods and applications of inhibitors in preparing pharmaceuticals
发明人：GUAN YOUFEI; LIANG ZICAI
权利人:GUAN YOUFEI; LIANG ZICAI; SUZHOU RIBO LIFE SCIENCE COMPANY LTD
摘要:Inhibitors that can inhibit expression of FAM3B gene to reduce the levels of expression products, or can combine the expression products to reduce the activity of promoting lipid synthesis of FAM3B gene product are provided, wherein the inhibitors are one or more inhibitors selected from the group consisting of small interfering RNAs, antisense oligonucleotides, antibodies against FAM3B proteins and active organic compounds. Cells, vectors or inhibitor compositions, comprising such inhibitors, methods for inhibiting expression of FAM3B gene or inhibiting the activity of promoting lipid synthesis of FAM3B gene product using the inhibitors are provided. Methods for treating diseases mediated by expression of FAM3B gene using such inhibitors and uses of the inhibitors in preparing pharmaceuticals for preventing and/or treating the disease mediated by FAM3B gene expression are also provided.

专利号:US-2013345116-A1
优先权日:2012-06-21
标题 :Composition Containing Trail for Prevention or Treatment of Metabolic Diseases
发明人：LEE HYE-JEONG
权利人:LEE HYE-JEONG
摘要:The present invention provides a pharmaceutical composition and a food composition containing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) as an active ingredient for prevention or treatment of metabolic diseases. The TRAIL according to the present invention can reduce blood glucose, neutral fat, cholesterol, and free fatty acid, and neutral fat in liver, and reduce the synthesis of fat, and promote the lipid metabolism, and thus can be effectively used for the prevention or treatment of metabolic diseases.