甲基环己烷置于catalyst G (Containing 0.50 Wtpercent Pt)体系中,360.0~400.0 °C,5.62 Mpa 条件下,以45%的收率获得正庚烷 参考文献:Dual Functional Catalyst For Selective Opening Of Cyclic Paraffins And Process For Using The Catalyst 标题:Dual Functional Catalyst For Selective Opening Of Cyclic Paraffins And Process For Using The Catalyst 摘要:已经开发出一种用于选择性开启环烷烃的催化剂.该催化剂包括第viii族金属,如铂,修饰剂组分,如铌或镱,分子筛,如uzm-16,以及耐火无机氧化物,如氧化铝.第viii族金属和修饰剂组分最好沉积在耐火无机氧化物上.还公开了使用该催化剂的方法.
专利号:WO-2021014395-A1 优先权日:2019-07-24 标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.
专利号:US-10604599-B2 优先权日:2018-05-29 标题:Method for green synthesis of uniform- and large-particle-size polystyrene particles 发明人:SHUANG CHENDONG; ZHOU WEIWEI; WANG YUNSHU; LI AIMIN; LI QIMENG; LIU LILI; WANG WEI; ZHANG YI 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING UNIV & YANCHENG ACADEMY OF ENVIRONMENTAL PROTECTION TECHNOLOGY AND ENGINEERING 摘要:A method for green synthesis of uniform- and large-particle-size polystyrene particles, comprising steps of: prepolymerizing styrene at 70â–¡ to 75â–¡ for 1 h to 6 h in advance while stirring, adding divinylbenzene dissolved with initiators to the styrene, and stirring for 10 min to 30 min to obtain oil phase; heating lactic acid or an aqueous solution of lactic acid to 70â–¡ to 80â–¡, adding the oil phase to dispersed phase by a constant-pressure device, maintaining the temperature for 2 h, heating to 80±5â–¡ and then maintaining the temperature for 1 h, and heating to 85±5â–¡ and then maintaining the temperature for 3 h to 6 h, to obtain polystyrene particles with a uniform particle size ranging from 0.7 mm to 2.0 mm.
专利号:US-2007287843-A1 优先权日:2004-04-07 标题 :Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol 发明人:CABAJ JOHN E; PARIZA RICHARD J; LUKESH JULIE M 权利人:CABAJ JOHN E; PARIZA RICHARD J; LUKESH JULIE M 摘要:Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved Y-THCIY-THC ratios are achieved. The intermediates may be cyclic compounds prepared from 2-Carene. There is also provided a scaleable process for the preparation of (+)-p-menth-2-ene-1,8-diol, another intermediate used in the synthesis of delta-9-tetrahydrocannibinol.
专利号:US-2019047933-A1 优先权日:2016-03-15 标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid 发明人:ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÜCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám 权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC 摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme
专利号:US-2016031800-A1 优先权日:2013-03-14 标 题:Synthesis of chiral kynurenine compounds and intermediates 发明人:TRETYAKOV ALEXANDER; DROUET KEITH E; SANDERS WILLIAM 权利人:VISTAGEN THERAPEUTICS INC 摘要:Provided are methods for the synthesis of compounds including chiral kynurenine compounds, intermediates useful for the synthesis thereof, and related compounds. For example, methods are provided for the synthesis of L-4-chlorokynurenine.
专利号:WO-2022256490-A9 优先权日:2021-06-03 标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus 发明人:LOCKWOOD MARK 权利人:ANTIOS THERAPEUTICS INC 摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.
参考文献:10.3390/ijms12063989 摘要:Thomas PA, Marvey BB, Ebenso EE. Metathesis of fatty acid ester derivatives in 1,1-dialkyl and 1,2,3-trialkyl imidazolium type ionic liquids. Int J Mol Sci. 2011;12(6):3989–97. 参考文献:10.1107/s1600536811006659 摘要:Qian JJ, Hu XR, Gu J, Wu SX. Eprosartan mesylate, an angiotensin II receptor antagonist. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o770–1. 参考文献:10.1371/journal.pone.0020897 摘要:Bardaweel S, Ghosh B, Chou T, Sadowsky MJ, Wagner CR. E. coli Histidine Triad Nucleotide Binding Protein 1 (ecHinT) Is a Catalytic Regulator of D-Alanine Dehydrogenase (DadA) Activity In Vivo. PLoS ONE. 2011 Jul 06;6(7):e20897. doi: 10.1371/journal.pone.0020897. 参考文献:10.3390/molecules16075916 摘要:Alemán-Vázquez LO, Cano-Domínguez JL, Torres-García E, Villagómez-Ibarra JR. Industrial application of catalytic systems for n-heptane isomerization. Molecules. 2011 Jul 14;16(7):5916–27. 参考文献:10.1016/j.plaphy.2011.06.008 摘要:Lawo NC, Weingart GJF, Schuhmacher R, Forneck A. The volatile metabolome of grapevine roots: First insights into the metabolic response upon phylloxera attack. Plant Physiology and Biochemistry. 2011 Sep;49(9):1059–63. doi: 10.1016/j.plaphy.2011.06.008.