CAS: 173334-58-2; (2S,4S,5S,7S)-5-Amino-N-(3-Amino-2,2-Dimethyl-3-Oxopropyl)-4-Hydroxy-2-Isopropyl-7-(4-Methoxy-3-(3-Methoxypropoxy)Benzyl)-8-Methylnonanamide Hemifumarate

上下游产品

CAS号1236549-06-6 δN-苄氧基羰基阿利克仑 | CAS号110-17-8 富马酸,反丁烯二酸 | CAS号173338-07-3 [1S-[1R*(R*),2R... | CAS号173334-57-1 阿利吉仑 | CAS号173399-03-6 (2S,4S,5S,7S)-7... | CAS号324763-47-5 (αS,γS,δS,ζS)-N... | CAS号324763-51-1 3-氨基-2,2-二甲基丙酰胺 | CAS号503-74-2 异戊酸 | CAS号67744-70-1 3-氨基-2,2-二甲基丙腈 | CAS号7505-93-3 2-氰基-2-甲基丙酰胺 | CAS号173334-57-1 阿利吉仑

专利信息

专利号:US-9056816-B2
优先权日:2011-10-25
标 题:Process for the preparation of aliskiren
发明人：BISWAS SUJAY; SRIMURUGAN SANKARESWARAN; KUMAR ANJUL; PANDA ATULYA KUMAR; JAMSHAD DANISH; MASAND MUKESH; BISWAS BIDYUT; BANSAL VIKAS; GUPTA ASHISH KUMAR; VIR DHARAM
权利人:JUBILANT LIFE SCIENCES LTD
摘要:The present invention provides a novel process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, or a salt thereof, preferably Aliskiren hemifumarate.

专利号:WO-2011148392-A1
优先权日:2010-05-28
标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

专利号:WO-2012078147-A1
优先权日:2010-12-08
标 题:A process for the preparation of intermediates useful in the production of aliskiren
发明人：BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
权利人:WATSON LAB INC; BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
摘要:A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.

专利号:US-9187409-B2
优先权日:2010-10-19
标 题 :Synthesis of Aliskiren
发明人：SHANKAR RAMA; RAO VADALI LAKSHMANA; KUMAR PALLA VIJAY; SWAMY SAIDUGARI; RAO DASARI SRINIVASA; POTLA SRINIVASA RAO; NAGARAJU MITTAPELLY; RAVIKANTH JALDU; RAVI VIJAYA KRISHNA; MANUKONDA SESHADRI RAO; RAMESH DANDALA
权利人:SHANKAR RAMA; RAO VADALI LAKSHMANA; KUMAR PALLA VIJAY; SWAMY SAIDUGARI; RAO DASARI SRINIVASA; POTLA SRINIVASA RAO; NAGARAJU MITTAPELLY; RAVIKANTH JALDU; RAVI VIJAYA KRISHNA; MANUKONDA SESHADRI RAO; RAMESH DANDALA; MYLAN LAB LTD
摘要:The present invention provides novel process for the preparation of renin inhibitor Aliskiren or its derivatives, and its pharmaceutically acceptable salts. The present invention also provides novel intermediates used in the preparation of Aliskiren.

专利号:EP-2313386-B1
优先权日:2008-07-23
标 题:Synthesis routes to 2(s),4(s),5(s),7(s)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides
发明人：VRIES DE ANDREAS HENDRIKUS MARIA; VERZIJL GERARDUS KAREL MARIA; HERMSEN PETRUS JOHANNES; CASTELIJNS ANNA MARIA CORNELIA FRANCISCA
权利人:DSM IP ASSETS BV
摘要:The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.

专利号:ES-2358536-T3
优先权日:2005-09-28
标题 :SYNTHESIS OF RENINAL INHIBITORS INVOLVING A CYCLOADITION REACTION.