CAS: 20348-09-8; 2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One

上下游产品

CAS号1268818-15-0 2-(2-nitropyrid... | CAS号16867-03-1 2-氨基-3-羟基吡啶 | CAS号79-11-8 氯乙酸 | CAS号79-04-9 氯乙酰氯 | CAS号105-36-2 溴乙酸乙酯 | CAS号337463-88-4 L-4-氰基苯丙氨酸 | CAS号201230-82-2 carbon monoxide | CAS号15128-82-2 3-羟基-2-硝基吡啶 | CAS号93765-23-2 2-(2-aminopyrid... | CAS号122450-96-8 7-溴-2H-吡啶并[3,2-... | CAS号337463-64-6 6-硝基-2H-吡啶并[3,2... | CAS号34968-16-6 4-Allyl-2H-pyri... | CAS号20348-23-6 3,4-二氢-2H-吡啶并[3...

3-羟基-2-硝基吡啶置于铁粉,Potassium Carbonate,溶剂黄146体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 3.83H,反应生成2H-吡啶并[3,2-B][1,4]恶嗪-3(4H)-酮
参考文献:在fe /乙酸存在下通过2-(2-硝基苯氧基)乙腈加成物的还原环化反应合成2 H-1,4-苯并恶嗪-3-(4 H)-Ones的简便方法
标题:在fe /乙酸存在下通过2-(2-硝基苯氧基)乙腈加成物的还原环化反应合成2 H-1,4-苯并恶嗪-3-(4 H)-Ones的简便方法
摘要:本文描述了合成1,4-苯并恶嗪-3-(4 H)-One的简单途径.该方法涉及在fe /乙酸存在下2-(2-硝基苯氧基)乙腈加合物的还原环化,其收率非常好至优异.该系统与其他各种功能组兼容.
Doi:10.1016/j.Tet.2010.11.095

专利信息

专利号:WO-2023086801-A1
优先权日:2021-11-09
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-9018387-B2
优先权日:2010-06-11
标 题:Complexes of imidazole ligands
发明人：NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; LEI XINJIAN; SPENCE DANIEL P; IVANOV SERGEI VLADIMIROVICH; BAILEY III WADE HAMPTON
权利人:NORMAN JOHN ANTHONY THOMAS; PEREZ MELANIE K; LEI XINJIAN; SPENCE DANIEL P; IVANOV SERGEI VLADIMIROVICH; BAILEY III WADE HAMPTON; AIR PROD & CHEM
摘要:Metal imidazolate complexes are described where imidazoles ligands functionalized with bulky groups and their anionic counterpart, i.e., imidazolates are described. Compounds comprising one or more such polyalkylated imidazolate anions coordinated to a metal or more than one metal, selected from the group consisting of alkali metals, transition metals, lanthanide metals, actinide metals, main group metals, including the chalcogenides, are contemplated. Alternatively, multiple different imidazole anions, in addition to other different anions, can be coordinated to metals to make new complexes. The synthesis of novel compounds and their use to form thin metal containing films is also contemplated.

专利号:WO-2011123558-A1
优先权日:2010-04-01
标题:Synthesis of metal complexes
发明人：DOMBEK BERNARD DUANE; CHERIAN ANNA E
权利人:NOVOMER INC; DOMBEK BERNARD DUANE; CHERIAN ANNA E
摘要:The present disclosure provides novel methods of making aluminum porphyrin carbonyl cobaltate complexes, including methods of reacting a hydrido cobalt carbonyl with an alkyl aluminum porphyrin to generate a carbonyl cobaltate salt of the aluminum porphyrin. Also provided are methods of making hydrido cobalt tetracarbonyl.

专利号:WO-2024184661-A1
优先权日:2023-03-09
标 题 :Synthesis of bicycle toxin conjugates, and intermediates thereof
发明人：LIMB DARREN; MOSS WILLIAM; WITTY DAVID; ZHANG JIE; LIN JINGUANG
权利人:BICYCLETX LTD
摘要:The present invention relates methods of preparing Bicycle toxin conjugates, and intermediates thereof.

专利号:US-2013131343-A1
优先权日:2009-12-07
标 题:Microwave-assisted synthesis of n-heterocyclic carbene transition metal complexes
发明人：NAVARRO OSCAR; WINKELMANN OLE H
权利人:NAVARRO OSCAR; WINKELMANN OLE H; UNIV HAWAII
摘要:Microwave heating is used to synthesize NHC-transition metal complexes. Reaction times for the formation of NHC-transition metal complexes is greatly reduced. The speed of the reactions allows for otherwise problematic air handling of reagents. Apparatus for carrying out the reactions is less complex than conventional apparatus and requires less energy to achieve the desired temperatures. Methods utilize salts of NHC's which overcomes the oftentimes difficult preparation of free carbenes for formation of the corresponding transition metal complexes.