专利号:WO-2025119975-A1 优先权日:2023-12-04 标 题:A method for synthesis of harmine 发明人:HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN 权利人:RECONNECT LABS AG 摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.
专利号:US-2023202980-A1 优先权日:2019-08-30 标题:N-(2-Aminophenyl)-Prop-2-Enamide Derivatives, and Uses Thereof in the Treatment of Cancer 发明人:RADHAKRISHNAN SRIDHAR; TENEN DANIEL G; LIU BEE HUI; VU LE KIM ANH; GO MEI LIN; CHAI LI; GAO CHONG; KAMAL AHMED; SUNKARI SATISH; AYINAMPUDI VENKATA SUBBARAO; SYED RIYAZ; LIU MIAO 权利人:NAT UNIV SINGAPORE; THE BRIGHAM AND WOMEN’S HOSPITAL INC; INDIAN INSTITUTE OF CHEMICAL TECH 摘要:Provided herein are N-(2-aminophenyl)-prop-2-enamide derivatives, such as those of Formula (I), methods for the synthesis thereof, and uses thereof in the treatment of cancer, such as SALL4-expressing cancer, in a cell or subject in need thereof.
专利号:US-8921580-B2 优先权日:2012-05-09 标 题 :Methods and systems for the formation of cyclic carbonates 发明人:HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.
专利号:US-6987189-B2 优先权日:2001-05-31 标题:Short synthesis of pyridine-based pharmaceutical intermediates 发明人:COMINS DANIEL L; HUANG SHENLIN 权利人:UNIV NORTH CAROLINA STATE 摘要:A method of making a compound of Formula VI: n nwherein Tr is a triphenyl group; R 1 , R 2 and R 3 are each independently selected from the group consisting of H, C1–C4 alkyl, C1–C4 alkoxy, aryl, heteroaryl, and arylalkyl; R 4 is C2–C6 alkyl, and R 5 and R 6 are each independently H or C1–C4 alkyl, involves the step of reacting a compound of Formula V: n nwith Tr-OH to produce a compound of Formula VI. The compounds of Formula VI are useful as intermediates in the manufacture of antibiotic agents. Methods of making compounds of Formula V, and intermediates made or used in the foregoing methods, are also described.
专利号:US-2002193606-A1 优先权日:2001-05-31 标 题 :Short synthesis of pyridine-based pharmaceutical intermediates
专利号:US-2003166941-A1 优先权日:2001-05-31 标题 :Short synthesis of pyridine-based pharmaceutical intermediates