CAS: 1118767-16-0; (S)-22-(Tert-Butoxycarbonyl)-43,43-Dimethyl-10,19,24,41-Tetraoxo-3,6,12,15,42-Pentaoxa-9,18,23-Triazatetratetracontanoic Acid

相似化合物

2618724-23-3 2253870-61-8 1188328-39-3

(2-(2-Aminoethoxy)Ethoxy)Acetic Acid Benzyl Ester置于甲醇,1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,二乙胺,N,N-二异丙基乙胺,三氟乙酸,Lithium Hydroxide体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 8.5H,反应生成索玛鲁肽侧链
参考文献:一种液相法制备索马鲁肽侧链的方法
标题:一种液相法制备索马鲁肽侧链的方法
摘要:一种制备索马鲁肽侧链的方法:将起始原料2‑(2‑氨基乙氧基)乙醇的氨基用r1保护,接着与α卤代酯发生亲核取代反应延长碳链,一锅法制得两端保护的脂肪链,该脂肪链分别脱除一端保护基并经缩合得到化合物7,脱除r1保护基得到化合物8,与芴甲氧羰基‑l‑谷氨酸1‑叔丁酯进行缩合反应得到化合物10,脱除芴甲氧羰基,再与18‑(叔丁氧基)‑18氧代十八烷酸进行酰胺化缩合反应,得到化合物13,脱除r2保护基得到目标产物链1;本发明方法相对于固相合成成本更加低廉,保护基的选择更加广泛,具有工业化生产应用前景;

专利信息

专利号:WO-2025078040-A1
优先权日:2023-10-09
标 题 :Lysine salt and method of manufacturing a lysine derivative
发明人：HINTERMANN TOBIAS; SCHWINDLING JOACHIM; RÃœEFLI PASCAL; SCHÖNLEBER RALPH O; WILLIG FELIX; MELZIG LAURIN; ERMERT PHILIPP; KÃœMIN MICHAEL; SCHWIZER NATASCHA; SCHNEIDER ANGELIKA; SCHMID LUCIUS
权利人:BACHEM HOLDING AG
摘要:The invention relates to a Bsmoc-protected lysine salt of formula (1 X ), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1 X ) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.

专利号:US-9732137-B2
优先权日:2007-12-28
标 题 :Semi-recombinant preparation of GLP-1 analogues
发明人：LAU JESPER FAERGEMAN; ANDERSEN ASSER SLOTH; BLOCH PAW; LAU JESPER; GARIBAY PATRICK WILLIAM; KRUSE THOMAS; NØRBY INGA SIG NIELSEN; JESSEN CLAUS ULRICH; CHRISTENSEN CASPAR; NORRILD JENS CHRISTIAN
权利人:LAU JESPER FAERGEMAN; ANDERSEN ASSER SLOTH; BLOCH PAW; LAU JESPER; GARIBAY PATRICK WILLIAM; KRUSE THOMAS; NØRBY INGA SIG NIELSEN; JESSEN CLAUS ULRICH; CHRISTENSEN CASPAR; NORRILD JENS CHRISTIAN; NOVO NORDISK AS
摘要:A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.

专利号:CN-118955683-A
优先权日:2024-08-09
标题:Semex lattice Synthesis method of lupeptide

专利号:CN-118812694-A
优先权日:2024-08-09
标 题 :Synthesis method of amino acid with side chain Lys and application of amino acid in semaglutin

专利号:CN-119707884-A
优先权日:2024-12-31
标 题:Synthesis process of racemic (2R, 4R)-4-aminotetrahydrofuran-2-carboxylic acid methyl ester hydrochloride