CAS: 1185-33-7; 2,2-Dimethylbutan-1-Ol

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595-37-9 5129-40-8 1565-80-6

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CAS号50-00-0 甲醛 | CAS号78-84-2 异丁醛 | CAS号813-67-2 2,2-Dimethylbut... | CAS号75-83-2 2,2-二甲基丁烷 | CAS号28276-08-6 1,1-二甲基丙基氯化镁 | CAS号595-37-9 2,2-二甲基丁酸 | CAS号2094-75-9 2,2-二甲基丁醛 | CAS号920-39-8 异丙基溴化镁 | CAS号67-56-1 甲醇 | CAS号78-78-4 异戊烷 | CAS号595-37-9 2,2-二甲基丁酸 | CAS号19889-37-3 2-乙基-2-甲基丁酸 | CAS号1185-39-3 2,2-二甲基戊酸 | CAS号3124-44-5 2,2-dimethylbut... | CAS号25346-31-0 3-溴-3-甲基戊烷 | CAS号2094-75-9 2,2-二甲基丁醛 | CAS号66793-92-8 2,4,4-trimethyl... | CAS号62168-42-7 1-bromo-2,2-dim...

2,2-二甲基丁酸置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应生成2,2-二甲基-1-丁醇
参考文献:己醇结构异构体之间氢键的层次结构
标题:己醇结构异构体之间氢键的层次结构
摘要:氢键的强度和热稳定性影响缔合液体(例如高级醇)的整体性质.温度引起的氢键衰变转化为液体热容的不常见趋势,经常表现出巨大的平台或明显的最大值.介绍了在 260-340 K 温度范围内通过 Tian-Calvet 量热法得出的 16 种脂肪族己醇在液相中的实验同压热容.通过功率补偿 Dsc,可将 13 种化合物的温度范围扩展到 380 K.在所研究的化合物中,对于 6 种化合物,明确观测到热容温度依赖性的最大值低于 380 K.在推导余热容后,该最大值被放大并可识别 13 种物质(低于 400 K).对所有己醇异构体的纯样品进行分子动力学模拟,以解释观测到的趋势.氢键层次结构是根据散装液体的结构和能量描述符通过计算建立的.氢键的强度与本体液体中烷基侧链对羟基部分施加的空间位阻程度直接相关.计算预测己醇异构体在液体中形成最弱的氢键,与观测到热容的非单调趋势的氢键相匹配.热容量最大值的位置对氢键强
Doi:10.1016/j.Molliq.2023.123804

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:WO-2024105700-A1
优先权日:2022-11-18
标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).

专利号:US-2023339844-A1
优先权日:2020-09-17
标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-6995289-B2
优先权日:2000-08-02
标题 :Process for synthesis of alpha, beta-unsaturated ketones
发明人：PATEL IAN; HOPES PHILIP
权利人:ASTRAZENECA AB
摘要:A method for the synthesis of an α,β-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low temperature. The synthesis is used in a process for making substituted 1,4-dihydropyridines wherein a vinylogous amide is prepared by reacting a 1,3-cyclohexanedione with a phenylethylamine. The α,β-unsaturated ketone can be reacted with a vinylogous amide to form a 1,5-diketone which can be converted to a substituted 1,4-dihydropyridine.

专利号:US-9409945-B2
优先权日:1999-10-04
标 题 :Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
发明人：DESLONGCHAMPS PIERRE; DORY YVES; BERTHIAUME GILLES; OUELLET LUC; LAN RUOXI
权利人:OCERA THERAPEUTICS INC
摘要:A library of macrocyclic compounds of the formula (I) n n n n n n n n n n n n where part (A) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) y — bivalent radical or a covalent bond; n where part (B) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) z — bivalent radical, or a covalent bond; n where part (C) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) t — bivalent radical, or a covalent bond; and n where part (T) is a —Y-L-Z— radical wherein Y is CH 2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.