专利号:US-8138330-B2 优先权日:2006-09-11 标 题 :Process for the synthesis of oligonucleotides 发明人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED 权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC 摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.
专利号:US-6765117-B2 优先权日:1997-10-24 标题:Process for stereoselective synthesis of prostacyclin derivatives 发明人:MORIARTY ROBERT M; PENMASTA RAJU; GUO LIANG; RAO MUNAGALA S; STASZEWSKI JAMES P 权利人:UNITED THERAPEUTIC CORP 摘要:An improved method is described for making 9-deoxy-PGF 1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF 1 -type compounds.
专利号:WO-2014059961-A1 优先权日:2012-10-15 标 题 :Method for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates 发明人:BÜTTNER HERMANN; Müller Jürgen; JONKER RAPHAEL; DOEDT SEBASTIAN; BOSSE TOBIAS; MAKRAN SEBASTIAN 权利人:BÜTTNER HERMANN 摘要:The invention relates to a synchronous CCU method (carbon dioxide capture and utilisation) for the absorption of carbon dioxide from flue gas and other CO 2 -containing substance sources and simultaneous synthesis of dialkyl carbonates and alkylene carbonates. The general subject matter of the invention is, in terms of a 'carbon dioxide capture' on the one hand, the absorption of CO 2 from flue gas and other CO 2 -containing substance sources with ammonia and/or amines to form ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates and, in terms of a 'carbon dioxide utilisation' on the other hand, the reaction of ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates with aliphatic, alicyclic or unsaturated alcohols, and including unsaturated aromatic alcohols to give dialkyl carbonates or alkylene carbonates in such a form that the CO 2 n absorption agent is re-released and fed back into the repetitive process again. A repetitive process control is extremely energy and CO 2 n efficient.
专利号:US-2022212159-A1 优先权日:2020-12-04 标 题:Process of synthesis of silica-based adsorbents, adsorbents and use 发明人:PONTES BITTENCOURT QUITETE CRISTINA; MOTA DE ALBUQUERQUE ELISE; DE JESUS CANHACI SIMONE; FEITOSA LEON FAGNER; FRAGA MARCO ANDRE 权利人:PETROLEO BRASILEIRO SA PETROBRAS; INSTITUTO NAC DE TECNOLOGIA INT 摘要:The present invention relates to a process of synthesis of silica-based adsorbents used in the CO2 capture process in oil fields with expressive volumes of associated CO2, aiming its subsequent use in processes of producing bioQAV and alcohol from the hydrogenation reaction. Adsorbents obtained based on silica and different metals have a high stability and activity in CO2 capture, at adsorption and desorption temperatures of 25° C., increasing the density of the silanol groups present in mesoporous silica, conducted by replacing Si in the crystal lattice with various metals. The insertion of elements in the structure is responsible for creating vacancies used to capture CO2, being characteristic of higher enthalpies involved in the process. Additionally, the exchange of silicon for metals is conducted during the hydrolysis process of the silica precursor, not requiring another step, in addition to being able to be conducted with low-cost precursors, such as chlorides, nitrates and isopropoxides, and an aqueous medium.
专利号:US-11377511-B2 优先权日:2020-03-31 标 题:Reducing agent monomer for preparing styrene-acrylic emulsion by oxidation-reduction reaction at room temperature, and synthesis method thereof 发明人:HUANG WENYAN; SUN QIUJIE; JIANG BIBIAO; XUE XIAOQIANG; YANG HONGJUN; JIANG LI; JIANG QIMIN 权利人:UNIV CHANGZHOU 摘要:A reducing agent monomer for preparing a styrene-acrylic emulsion by an oxidation-reduction reaction at room temperature and a synthesis method thereof are disclosed. Maleic anhydride (MAH) and dimethylethanolamine (DMEA) are used as raw materials to synthesize the reducing agent monomer: 4-(2-(dimethylamino)ethoxy)-4-oxobut-2-enoic acid, and the synthesis method involves inexpensive easily-available raw materials, simple synthesis conditions, and easy purification. With the synthesized reducing agent monomer as a reducing agent, potassium persulfate (KPS) as an oxidizing agent, water as a dispersion medium, sodium dodecyl sulfate (SDS) as an emulsifier, and styrene, butyl acrylate (BA), and methylmethacrylate (MMA) as comonomers, free-radical microemulsion polymerization is conducted at room temperature to obtain a styrene-acrylic emulsion. In the synthesis of the styrene-acrylic emulsion, a monomer conversion rate is high, and a styrene-acrylic emulsion with a high molecular weight and a branched structure can be obtained at room temperature.
专利号:US-8202985-B2 优先权日:2005-10-31 标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection 发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H 权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO 摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.
1: Zhang Q, Ning Z, Li X, Ning X, Wu F, Zhou J. Experimental study of CO2 capture by nanoparticle-enhanced 2-amino-2-methyl-1-propanol aqueous solution. RSC Adv. 2023 Nov 16;13(48):33644-33653. doi: 10.1039/d3ra06767j. 2: Garnick L, Bates C, Massarsky A, Spencer P, Sura P, Monnot AD, Maier A. Dose and exposure route analyses inform relationships between liver steatosis and 2-amino-2-methyl-1-propanol: Implications for hazard characterization. J Appl Toxicol. 2022 Dec;42(12):1873-1889. doi: 10.1002/jat.4308. Epub 2022 Mar 8. 44(3):316-332. doi: 10.1002/jat.4539. Epub 2023 Sep 16. 125(34):7502-7519. doi: 10.1021/acs.jpca.1c04898. Epub 2021 Aug 23.
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