专利号:US-6849650-B2 优先权日:1998-02-27 标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-11149034-B2 优先权日:2017-07-25 标 题:Derivatives of luciferin and methods for their synthesis 发明人:JARDINE MOEGAMAT ANWAR; RYLANDS MARWAAN 权利人:UNIV CAPE TOWN 摘要:6-Thio derivatives of D-luciferin, also referred to as D-thioluciferins, having the general structure of Formula (I) are provided. Methods for synthesising D-luciferin, its derivatives, and their related 2-cyanobenzothiazole precursors are also provided. These compounds are commercially valuable due to their application in optical imaging, particularly in bioluminescence imaging.
专利号:US-5618808-A 优先权日:1992-07-01 标 题 :Benzothiazepine and benzoxazepine derivatives as cholecystokinin receptor antagonists 发明人:NAGEL ARTHUR A 权利人:PFIZER 摘要:The present invention relates to novel substituted benzothiazepines and benzoxazepines of the formula ##STR1## wherein R 1 , R 2 , R 7 , R 8 , R 9 and X are as defined below, and to novel intermediates used in the synthesis of such compounds. n Such compounds are useful in the treatment and prevention of gastrointestinal disorders, pain and anxiety disorders.
专利号:US-2003130188-A1 优先权日:1998-02-27 标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
专利号:WO-2019021202-A1 优先权日:2017-07-25 标题:LUCIFERIN DERIVATIVES AND METHODS OF SYNTHESIS
专利号:CN-107964029-B 优先权日:2017-12-19 标 题:New synthesis method of 4, 7-dimethoxy-N-acetylneuraminic acid-fluorescein and intermediate thereof
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807.
合成参考文献
参考文献:10.1007/s00726-012-1440-6 摘要:Takemoto Y. Pressor response to L-cysteine injected into the cisterna magna of conscious rats involves recruitment of hypothalamic vasopressinergic neurons. Amino Acids. 2013 Mar;44(3):1053–60. doi: 10.1007/s00726-012-1440-6.