CAS: 2462-34-2; H-Val-Obzl.Hcl

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21760-98-5 46460-17-7 516-06-3

上下游产品

CAS号66447-55-0 B°C valine benz... | CAS号72-18-4 l-缬氨酸 | CAS号100-51-6 苯甲醇 | CAS号13734-41-3 B°C-L-缬氨酸 | CAS号100-39-0 溴化苄 | CAS号100-44-7 氯化苄 | CAS号140923-27-9 isopropoxycarbo... | CAS号1007884-62-9 2-(dimethylcarb... | CAS号1007884-61-8 benzyl 2-(dimet... | CAS号137862-53-4 缬沙坦 | CAS号3918-94-3 缬氨酰-缬氨酸

(6S)-6-Isopropyl-1-P-Methoxybenzylpiperazine-2,5-Dione置于盐酸,正丁基锂,Ammonium Cerium (Iv) Nitrate,三氟化硼乙醚体系中,用 四氢呋喃,正己烷,二氯甲烷,水,乙腈 用作溶剂,化学反应 120.25H,反应生成L-缬氨酸苄酯盐酸盐
参考文献:正交保护的schöllkopf'S Bis-Lactim醚用于α-氨基酸衍生物和二肽酯的不对称合成
标题:正交保护的schöllkopf'S Bis-Lactim醚用于α-氨基酸衍生物和二肽酯的不对称合成
摘要:摘要 的氮杂-烯醇化物的烷基化正交保护的手性双内酰亚胺醚与diastereocontrol,得到非常好水平电体进行反式烷基化的加合物,可以通过水解/氢化方法有效地脱保护,得到非蛋白原α氨基酸或二肽酯衍生品. 的氮杂-烯醇化物的烷基化正交保护的手性双内酰亚胺醚与diastereocontrol,得到非常好水平电体进行反式烷基化的加合物,可以通过水解/氢化方法有效地脱保护,得到非蛋白原α氨基酸或二肽酯衍生品.
Doi:10.1055/s-0035-1561943

专利信息

专利号:US-6342582-B1
优先权日:1989-12-04
标 题 :Reaction and dissolving medium for peptides and synthesis method using this medium
发明人：GALVEZ MARIE; MAURICE MARIE-FRANCE
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a reaction and dissolving medium for the synthesis of peptides. This reaction and dissolving medium for peptide synthesis and/or purification comprises a diluent A chosen from a group of water-immiscible solvents and a phenol B. By employing this reaction and dissolving medium, peptides can be synthesized which are useful as medicaments, vaccines, agro-foodstuff products or plant protection products.

专利号:EP-1831186-B1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan
发明人：ZUPANCIC SILVO; PECAVAR ANICA; ZUPET ROK
权利人:KRKA D D NOVO MESTO
摘要:This invention relates to an improved process for preparing a valsartan, or a pharmaceutically acceptable salt thereof, or pharmaceutical preparation containing either entity wherein a compound of formula (II) nor a salt thereof, is reacted with valine or an ester or a salt thereof in a solvent selected from the group consisting of methylene chloride, chloroform, butyl chloride, isopropyl acetate and tert -butyl methyl ether to form a compound of formula (IV) nwhich is then acylated to form a compound of formula (VI) nwherein R is hydrogen, alkyl, alkenyl or benzyl; which is then deprotected to give valsartan, and may be converted to a pharmaceutically acceptable salt and/or a pharmaceutical formulation. The invention also covers intermediates of formula (IV) and (VI) wherein R=H.

专利号:US-8288561-B2
优先权日:2007-05-07
标 题:Process for preparing valsartan
发明人：KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR
权利人:KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR; CIPLA LTD
摘要:An N-[(2′-(1-triphenyl methyl tetrazole-5-yl)biphenyl]-4-yl]methyl]-L-valine benzyl ester organic salt of formula (IVA) wherein A represents an organic carboxylic acid, a process for its preparation and its use in the synthesis of valsartan or salts thereof.

专利号:WO-2006058701-A1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan

专利号:IE-904349-A1
优先权日:1989-12-04
标题:Reaction and dissolving medium for peptides and method for¹the synthesis of peptides using this medium

专利号:AU-648764-B2
优先权日:1989-12-04
标题 :Reaction and dissolving medium for peptides and method for the synthesis of peptides using this medium