CAS: 25637-16-5; 4-Bromotetrahydropyran

上下游产品

Tetrahydro-pyran-4-ol formaldehyd homoalylic alcohol hydrogen bromide 1,3,5-tribromo-pentane tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl esteracetic acid 2,6-di-tert-butyl-4-hydroxy-3-[hydroxy-(tetrahydro-pyran-4-yl)-methyl]-phenyl ester 4-phenyltetrahydro-2H-pyran 1,3-dibromo-5-(methoxy)methoxypentane

四氢吡喃-4-甲酸置于碘苯二乙酸,Potassium Bromide体系中,用87%的收率获得4-溴四氢吡喃
参考文献:高价碘试剂对立体受阻羧酸的脱羧溴化反应
标题:高价碘试剂对立体受阻羧酸的脱羧溴化反应
摘要:立体受阻的三维(3D)烷基卤化物是各种反应的有希望的前体;但是,它们难以通过常规反应合成.我们提供了使用市售的(diacetoxyiodo)苯和溴化钾(自然界中最稳定和最便宜的溴源之一)对位阻3D脂肪族羧酸进行脱羧溴化的高效实用方法.本方法的特点是不含金属/ Br 2无体系,温和的反应条件,在室温下空气中一锅操作,广泛的官能团相容性和克级合成能力.这种高效的反应可以以高收率或高收率干净地将各种羧酸(高度紧张/天然存在/与药物相关的支架的最便宜和最容易获得的来源)转化为相应的烷基溴化物.
Doi:10.1021/acs.Oprd.0C00130

专利信息

专利号:US-3644427-A
优先权日:1970-02-13
标 题:Synthesis of 3-haloalkyl hydrocarboncarboxylates and 4-halotetrahydropyrans
发明人：STAPP PAUL R
权利人:PHILLIPS PETROLEUM CO
摘要:A 3-HALOALKY HYDROCARBONCARBONXYLATE AND A 4-HALOTETRAHYDROPYRAN ARE PRODUCED BY REACTING A 1-ALKENE, (HCHO)N'' A HYDROGEN HALIDE AND AN ACID HALIDE AT A TEMPERATURE IN THE RANGE OF -80 TO -30* C., WHEREIN N IS THE INTEGER 1 OR GREATER.

专利号:WO-2023131254-A1
优先权日:2022-01-06
标 题 :Pseudouridine modified at n1 position and use thereof in mrna synthesis
发明人：LI SONG; GUO CHUANXIN; CAI XIAORU; QIAN QIJUN
权利人:MAXIRNA SHANGHAI PHARMACEUTICAL CO LTD; MAXIRNA ZHEJIANG TECH CO LTD
摘要:Provided in the present invention are a pseudouridine modified at an N1 position and the use thereof in mRNA synthesis. Specifically, the compound of the present invention comprises compounds represented by formula I and formula II, and the definition of each group in the formula is as described herein. The compound of the present invention can be used for preparing mRNA to reduce the autoimmunogenicity of the mRNA, improve the stability of the mRNA itself, and/or enhance the expression time and expression efficiency of the mRNA in a target cell.

专利号:US-9051289-B2
优先权日:2013-09-26
标 题 :Process and intermediates for preparing GPR40 agonists
发明人：DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN
权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.

专利号:US-12103929-B2
优先权日:2018-06-25
标题:Tricyclic compounds
发明人：FANG HAIQUAN; CHEN MINGMING; YANG GUIQUN; DU YUELEI; WANG YANPING; WU TONG; LI QINGLONG; ZHANG LEI; HU SHAOJING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.