专利号:US-4151205-A 优先权日:1975-01-27 标题 :Synthesis of vitamin E 发明人:COHEN NOAL; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:A synthesis of vitamin E in racemic or optically active forms from methacryolein or beta-hydroxyisobutyric acid including intermediates in this synthesis.
专利号:US-4051153-A 优先权日:1975-01-27 标题 :Intermediates in the synthesis of vitamin E 发明人:COHEN NOAL; SAUCY GABRIEL 权利人:HOFFMANN LA ROCHE 摘要:A synthesis of vitamin E in racemic or optically active forms from methacryolein or beta-hydroxyisobutyric acid including intermediates in this synthesis.
专利号:US-6211329-B1 优先权日:1997-06-26 标题:Process for preparation of a dendritic polyol 发明人:REHNBERG NICOLA; PETTERSSON BO; ANNBY ULF; MALMBERG MATS 权利人:PERSTORP AB 摘要:A process for synthesis of a polymeric polyalcohol substantially and preferably built up form polyester units and composed of a monomeric or polymeric initiator molecule to which at least one dentritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymericor monomeric branching chain extender having three reactive functions of which two are hydroxyl groups. The two hydroxyl groups of the ranching chain extender is acetal protected by reaction between said two hydroxyl groups and an acetal-forming carbonyl compound, preferably an aldehyde. The acetal protected branching chain extender is then employed for addition to the initiator molecule of a first branching generation followed by an optional deprotection of the hydroxyl groups by decomposition of acetals and for addition in repeated steps of further branching generations. Additions of branching generations individually employ an acetal protected branching chain extender synthesized from the same or a different branching chain extender and/or acetal-forming carbonyl compound and addition of a branching generation is optionally followed by addition of a spacing generation.
专利号:US-10266467-B2 优先权日:2017-08-02 标 题:Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols 发明人:CHAKRABORTY SUMIT; HEMBRE ROBERT THOMAS 权利人:EASTMAN CHEM CO 摘要:A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H 2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H 2 . The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.
专利号:US-4082775-A 优先权日:1975-07-07 标 题 :Preparation of d, l-pantolactone 发明人:COUDERC PIERRE; HILMOINE SERGE 权利人:CHARBONNAGES STE CHIMIQUE 摘要:The invention relates to a method for the synthesis of D, L-pantolactone by the reaction of (1) of hydroxypivaldehyde with hydrocyanic acid produced in situ followed by (2) hydrolysis of the cyanohydrin obtained. The pantolactone may then be separated from the reaction mixture. Each of the reactions (1) and (2) are conducted under closely controlled conditions of concentration, temperature, pH and time and, by virtue of these conditions, a yield exceeding 90% may be obtained.
专利号:US-9676783-B2 优先权日:2008-10-22 标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds 发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN 权利人:ARRAY BIOPHARMA INC 摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.