大豆甙元置于吡啶,咪唑,4-二甲氨基吡啶,三氟化硼乙醚,Potassium Carbonate,苯硫酚体系中,用 四氢呋喃,N-甲基吡咯烷酮,甲醇,二氯甲烷,氯仿 作为反应溶剂,化学反应 4.0H,反应生成 豆苷 参考文献:Facile Synthesis Of Flavonoid 7-O-Glycosides 标题:Facile Synthesis Of Flavonoid 7-O-Glycosides 摘要:Highly Regioselective Removal Of The 7-O-Acylgroups Of The Peracyated Flavones,Isoflavones,And Flavonolsyl(Phsh,Imidazole,Nmp) Followed By Effective Glycosylation With Glycosyl Trifluoroacetimidates (Bf3.Et2O) And Cautious Deprotection Of The Acyl Groups Under Basic Conditions Afforded The Desired 7-O-Flavonoid Glycosides In Satisfactory Yields. DOI:10.1021/jo034553E
专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2009062555-A1 优先权日:2007-08-28 标 题 :Synthesis of Isoflavone 发明人:HARMS ARTHUR E 权利人:HARMS ARTHUR E 摘要:The invention provides a process of manufacturing an isoflavone of the general formula 7 n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 each independently are H, OH, or an alkoxy, provided at least one of R 1 , R 2 , R 3 , and R 4 being OH, and one being alkoxy, or at least 2 groups being OH, comprising providing ketone (3) n n n n n n n n n n wherein R 1 , R 2 , R 3 , and R 4 are as stated above, combining (3) with trialkylortho formate, and a Lewis or Bronsted acid to produce the isoflavone, precipitating the isoflavone.
专利号:US-8969596-B2 优先权日:2008-08-14 标题:Synthesis of equol 发明人:STEFFAN BERT 权利人:STEFFAN BERT 摘要:Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.
专利号:US-6849701-B2 优先权日:2001-03-02 标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers 发明人:NORTON TUCKER 权利人:DU PONT 摘要:A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.
专利号:US-7202398-B2 优先权日:2002-08-16 标 题 :Chalcone isomerase 发明人:MCGONIGLE BRIAN 权利人:DU PONT 摘要:An isolated nucleic acid fragment encoding a chalcone isomerase is disclosed. Also of concern is the synthesis of a recombinant DNA construct encoding all or a portion of the chalcone isomerase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the chalcone isomerase in a transformed host cell.
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合成参考文献
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