CAS: 67843-74-7; (S)-Epichlorohydrin

上下游产品

CAS号106-89-8 环氧氯丙烷 | CAS号621-84-1 氨基甲酸苄酯 | CAS号3132-64-7 环氧溴丙烷 | CAS号14199-15-6 对羟基苯乙酸甲酯 | CAS号108-95-2 苯酚 | CAS号67800-61-7 (S)-3-chloro-2-... | CAS号96-23-1 1,3-二氯丙醇 | CAS号616-23-9 2,3-二氯-1-丙醇 | CAS号4248-19-5 氨基甲酸叔丁酯 | CAS号51594-55-9 左旋环氧氯丙烷 | CAS号56715-13-0 (R)-(+)-阿替洛尔 | CAS号148857-42-5 (S)-2-(3-氯-2-羟基... | CAS号22910-07-2 1,3-bis(phenyls... | CAS号97798-50-0 (S)-phenyl glyc... | CAS号198226-53-8 (R)-2-chloro-6-... | CAS号184488-19-5 (S)-2-((2-氟苯氧基)... | CAS号19667-37-9 2-(3-氯-2-羟基丙基)异... | CAS号256372-58-4 (S)-2-((4-(三氟甲基... | CAS号181140-34-1 (R)-N-环氧丙基邻苯二甲酰亚胺 | CAS号86728-93-0 甲基 (S)-4-氯-3-羟基丁酸酯

(S)-1,3-Dichloro-1-Propanol置于氢氧化钾体系中,用 甲醇 作为反应溶剂,以51%的收率获得产物右旋环氧氯丙烷
参考文献:Preparative Production Of Optically Active Esters And Alcohols Using Esterase-Catalyzed Stereospecific Transesterification In Organic Media
标题:Preparative Production Of Optically Active Esters And Alcohols Using Esterase-Catalyzed Stereospecific Transesterification In Organic Media
摘要:
DOI:10.1021/ja00321A033

专利信息

专利号:US-9284306-B2
优先权日:2012-05-11
标题 :(R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel
发明人：GAGLIARDI STEFANIA; CONSONNI ALESSANDRA; MAILLAND FEDERICO; BULGHERONI ANNA
权利人:POLICHEM SA
摘要:(R)-Nifuratel is disclosed together with its use as bactericide and bacteriostatic agent as well as the pharmaceutical compositions containing the same; (R)-nifuratel has been surprisingly found to possess a better antimicrobial profile than either nifuratel racemate or (S)-nifuratel. A new procedure for the synthesis of both (R)-Nifuratel and (S)-Nifuratel is also disclosed.

专利号:US-9233989-B2
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof
发明人：REDDY DUMBALA SRINIVASA; BALAMKUNDU SEETHARAM SINGH; RAMESH REMYA
权利人:COUNCIL SCIENT IND RES
摘要:The invention discloses silaanalogs of oxazolidinone compounds, to pharmaceutical compositions and to the synthesis of the oxazolidinone derivatives of formula I. The invention further relates to methods of treating a subject suffering with gram positive pathogens including those resistant to methicillin and vancomycin using the compound(s) or modulation of coagulation properties of blood-clotting cascade or compositions of the oxazolidinone derivatives of the invention.

专利号:WO-2013046211-A1
优先权日:2011-09-27
标 题 :Processes for the preparation of 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl) phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; VENKAT REDDY BUTHUKURI
摘要:TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

专利号:US-10647672-B2
优先权日:2017-10-03
标 题:Modulators of cell adhesion, methods and compositions therefor
发明人：BLASCHUK OREST WILLIAM
权利人:Zonula Incorporated; ZONULA INC
摘要:Compounds with activity as modulators of cell adhesion are disclosed. The compounds are derivatives of piperidin-4-amine. In some embodiments, a compound can be linked to a targeting agent, a pharmaceutically active substance and/or a support material. Methods for enhancing or inhibiting classical cadherin-mediated functions are also disclosed. The compounds can be used for the treatment or prevention of a variety of diseases including cancer. Compositions and devices, including skin patches comprising a compound are also disclosed. In addition, methods of synthesis of the compounds are provided.

专利号:EP-2397141-A1
优先权日:2010-06-16
标 题:Process for the synthesis of beta-amino acids and derivatives thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to a process for the preparation of β-amino acids and derivatives thereof, which is especially suited for gliptins and particularly sitagliptin. A key step makes use of suitably derivatized epoxides or aziridines, which owing to a chirality provides a source of chirality for intermediates which are suitable for building up β-amino acids and similar compounds, in particular in the construction of the sitagliptin molecule.

专利号:WO-2006031179-A1
优先权日:2004-09-13
标 题:Process for preparation of phtalimide
发明人：KRIG ANN-SOFIE; THELIN MATS
权利人:ASTRAZENECA AB; KRIG ANN-SOFIE; THELIN MATS
摘要:The present invention is directed to a novel process for the synthesis of (S) -glycidyl phthalimide and to novel intermediates in the process. The process comprises, reacting a (R) -3 -Chloro-1,2-propanediol and phtalimide salt. Then reacting the product with trimethylorthoacetate and an essentially water free acid. Then reacting the product with acetyl halogenide and do a basic ester hydrolysis.