N-(4-(4-乙酰氨基-3-硝基苯基)-2-硝基苯基)乙酰胺置于镍 硫酸,氢气体系中,化学反应生成 3,3'-二氨基联苯胺 参考文献:Symmetric Bis-Benzimidazoles: New Sequence-Selective Dna-Binding Molecules 标题:Symmetric Bis-Benzimidazoles: New Sequence-Selective Dna-Binding Molecules 摘要:我们设计了一系列具有头对头取向的双苯并咪唑化合物,作为序列特异性 Dna 结合剂;寡核苷酸复合物的晶体学分析与 Dnase I 标记相结合,证实了双苯并咪唑核心基团的最佳预测位点是 5'-Aatt 四碱基对序列;这种序列特异性会抑制 A/t 位点的转录,可能是这些头对头双苯并咪唑具有细胞毒性和抗肿瘤作用的原因. DOI:10.1039/a901074B
专利信息
专利号:US-3865876-A 优先权日:1969-10-21 标 题 :Synthesis of 3,3{40 -diaminobenzidine from 3,3{40 -dichlorobenzidine 发明人:CHENEVEY EDWARD C; DRUIN MELVIN L; ORINGER KENNETH 权利人:CELANESE CORP 摘要:A process for the synthesis of 3,3''-diaminobenzidine from 3,3''dichlorobenzidine with NH3 in the presence of a catalyst consisting essentially of cuprous chloride. This process produces higher yields of a purer product than prior processes employing catalysts which are a mixture of cuprous chloride and calcium chloride.
专利号:US-6376475-B1 优先权日:1997-05-30 标 题 :Control of immune responses by modulating activity of glycosyltransferases 发明人:MARTH JAMEY D; PAULSON JAMES C 权利人:ABARON BIOSCIENCES INC; UNIV CALIFORNIA 摘要:The invention provides methods for inhibiting immune responses by inhibiting the biosynthesis of the sialyl galactosides that are involved in immune responses. In particular, B lymphocyte-mediated immune responses are mediated by interfering with synthesis of α2,6 sialylgalactosides, while T lymphocyte-mediated immune responses are inhibited by blocking synthesis of α2,3 sialylgalactosides. The inhibition is accomplished by, for example, inhibiting the activity of a glycosyltransferase involved in synthesis of the respective sialyl galactoside.
专利号:US-6242602-B1 优先权日:1999-03-29 标 题:One pot synthesis of 5,10-dihydrophenazine compounds and 5,10-substituted dihydrophenazines 发明人:GIRI PUNAM; BYKER HARLAN J; BAUMANN KELVIN L 权利人:GENTEX CORP 摘要:Dihydrophenazines and bis(dihydrophenazines) are prepared in high yield under commercially viable reaction conditions by reacting a catechol with a 1,2-diaminoaryl compound, wherein either the catechol or the 1,2-diaminoaryl compound is provided in at least 50% molar stoichiometric excess. The product may be oxidized to the corresponding phenazine, but is preferably derivatized at one or both of the 5,10-positions to form a monosubstituted or disubstituted dihydrophenazine or bis(dihydrophenazine). Most preferably, 5,10-dialkyl-5,10-dihydrophenazines are prepared starting from catechol and 1,2-diaminoaryl compound in a one pot synthesis. The products are useful as dyes, and in particular as chromophores in electrochromic systems.
专利号:US-4767881-A 优先权日:1987-07-13 标 题 :Synthesis of diphenyl phthlates 发明人:STAUTZENBERGER A LEE 权利人:HOECHST CELANESE CORP 摘要:Diphenyl esters of aromatic carboxylic acids are prepared in the presence of an organozirconium catalyst.
专利号:US-3681297-A 优先权日:1970-11-10 标 题 :Synthesis of polybenzothiazolines and polybenzothiazoles by reacting a dialdehyde with an aromatic bis-mercaptoamine 发明人:ALELIO GAETANO FRANCIS D 权利人:GAETANO FRANCIS D ALELIO 摘要:THIS INVENTION DEALS WITH A NOVEL, RELATIVELY SIMPLE PROCESS OF PREPARING POLYBENZOTHIAZOLINES, ((-NH-CH(-)-S-)>AR<(-NH-CH(-Z(-))-S-))N BY REACTING DIALDEHYDES, Z-(CH=O)2, AND (HS)2-AR(-NH2)2 IN A SOLVENT IN AN INERT ATMOSPHERE AND THEREAFTER OXIDIZING THE POLYBENZOTHIAZOLINES TO POLYBENZOTHIAZOLES, ((-N=C(-)-S-)>AR<(-N=C(-Z(-))-S-))N WHEREIN AR REPRESENTS A TETRAVALENT AROMATIC MOIETY IN WHICH THE NITROGEN AND SULFUR ATOMS IN EACH PAIR ARE DISPOSED ORTHO TO EACH OTHER AND Z REPRESENTS A DIVALENT HYDROCARBON MOIETY AS THE RESIDUE OF THE DIALDEHYDE, Z(CHO)2. NEW TYPES, AS WELL AS THE KNOW TYPES OF POLYBENZOTHIAZOLES HAVE BEEN PREPARED BY THIS PROCESS.
专利号:US-3943175-A 优先权日:1969-10-21 标题:Synthesis of pure 3,3'-diaminobenzidine 发明人:DRUIN MELVIN L; ORINGER KENNETH 权利人:CELANESE CORP 摘要:A process for the purification of crude 3,3'-diaminobenzidine comprising contacting it with sulfuric acid. The 3,3'-diaminobenzidine can be produced by the reaction of NH3 and 3,3'-dichlorobenzidine in the presence of various catalysts.
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合成参考文献
参考文献:10.1007/s12185-010-0512-1 摘要:Chuang S, Ichinohasama R, Yang C, Wang W, Chou C, Liao Y, Kuo S, Lin S. Multicentric primary intestinal EBV-positive diffuse large B cell lymphoma of the elderly presenting with perforation. International Journal of Hematology. 2010 Feb 13;91(3):534–8. doi: 10.1007/s12185-010-0512-1. 参考文献:10.1186/1471-2407-10-43 摘要:Zhang S, Guo D, Luo W, Zhang Q, Zhang Y, Li C, Lu Y, Cui Z, Qiu X. TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells. BMC Cancer. 2010 Feb 16;10():43. 参考文献:10.1186/2047-783x-14-s4-97 摘要:Halasová E, Adamkov M, Kavcová E, Matáková T, Musák L, Vybohová D, Janícková M, Mistuna D, Singliar A. Expression of anti-apoptotic protein survivin and tumor suppressor p53 protein in patients with pulmonary carcinoma. European Journal of Medical Research. 2009 Dec 07;14(Suppl 4):97. doi: 10.1186/2047-783x-14-s4-97. 参考文献:10.1007/s00432-010-0810-2 摘要:Zhong L, Wei K, Yang X, Pan H, Ye D, Wang L, Zhang Z. Overexpression of Galectin-1 is negatively correlated with pathologic differentiation grade in oral squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology. 2010 Feb 16;136(10):1527–35. doi: 10.1007/s00432-010-0810-2.