专利号:WO-2022218171-A1 优先权日:2021-04-16 标 题:Application of pineapple extract composition in whitening 发明人:LIU JITAO; WU DI; AN QUAN; LIU PINGPING; QUAN QIANGHUA; WANG CHANGTAO; SHI XIUQIN 权利人:Yunnan baiyao group health products co ltd; YUNNAN BAIYAO GROUP CO LTD; BEIQINGJIAHUA HUANGSHAN TECH CO LTD 摘要:An application of a pineapple extract composition in the preparation of a product having a whitening effect, the pineapple extract composition being prepared and obtained by extracting raw materials of the following components: pineapples, oat, highland barley, coix seeds, tremella polysaccharides and water. It has been proven by means of experimentation that the pineapple extract composition has an inhibiting effect on the activity of tyrosinase after acting on B16-F10 melanoma cells, and has a significant inhibitory effect on melanin synthesis of B16 cells.
专利号:US-6472531-B1 优先权日:1994-09-19 标题 :Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes 发明人:LABELL ELIZABETH SMITH; MCGILL JOHN MCNEILL; MILLER RANDAL SCOT 权利人:LILLY CO ELI 摘要:The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene hydrochloride, as well as processes for their preparation.
专利号:US-5688974-A 优先权日:1995-12-12 标 题 :Process for the preparation of an endothelin antagonist 发明人:DEVINE PAUL N; TSCHAEN DAVID M 权利人:MERCK & CO INC 摘要:The instant invention relates to a process for the stereoselective synthesis of a compounds of formula I: ##STR1##
专利号:US-5565199-A 优先权日:1995-02-07 标题 :Systems and methods for the synthesis of natural base steroidal hormones and more especially estrogens and progesterone and estrogen-like and progesterone-like compounds and their derivatives derived as phytohormones from herbaceous plants 发明人:PAGE ELLIOT W; RECTOR-PAGE LINDA G 摘要:Systems and methods for synthesizing natural base steroidal hormones and more especially estrogens and progesterone and estrogen-like and progesterone-like compounds and their derivatives which are derived in the form of phytohormones from herbaceous plants and formulated to provide a broad spectrum of estrogenic and/or progesterone activity for influencing physiological processes and biological functions. In particular, phytohormones (i.e. phytoestrogens and/or phytoprogesterone) are synthesized from herbaceous compounds selected from a group consisting of plants having a propensity for simulating estrogenic and/or progesterone hormonal activity that, when entering the bloodstream of a biological organism, either by means of oral ingestion, parenteral injection, or topical application, have a tendency to enhance, supplement and/or maintain estrogen and/or progesterone hormonal levels by means of replacement therapy within a biological organism.
专利号:US-6268499-B1 优先权日:1998-08-10 标 题 :Process and intermediates for preparation of substituted piperidine-epoxides 发明人:GUELLER ROLF; LOHRI BRUNO; SCHMID RUDOLF 权利人:HOFFMANN LA ROCHE 摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprisingepoxidation of a compound of formula 2 or a salt thereof n wherein A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.
专利号:US-6274735-B1 优先权日:1998-08-10 标 题 :Process and intermediates for preparation of substituted piperidines 发明人:LOHRI BRUNO; SCHMID RUDOLF; VIEIRA ERIC 权利人:HOFFMANN LA ROCHE 摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprising n a) hydroboration of a compound of formula 2 n A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.
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