CAS: 1008-91-9; 1-(Pyridin-4-yl)Piperazine

相似化合物

887775-50-0 942613-54-9 98010-38-9

上下游产品

CAS号63980-43-8 1-苄基-4-(4-吡啶) 哌嗪 | CAS号110-85-0 哌嗪 | CAS号626-61-9 4-氯吡啶 | CAS号1120-87-2 4-溴吡啶 | CAS号1143575-83-0 (R)-2-(2-chloro... | CAS号1143575-87-4 [1-(2-chloro-5-... | CAS号1143575-85-2 (2-chloro-5-oxo... | CAS号57260-71-6 1-B°C-哌嗪 | CAS号74901-69-2 2,4-二氯-6,7-二氢噻吩... | CAS号1143575-82-9 (R)-2-(2-chloro... | CAS号204693-44-7 3,5-Dibromo-N-{... | CAS号796856-41-2 1-(2,6-二氯吡啶-4-基)哌嗪

4-溴吡啶置于palladium On Activated Charcoal 甲酸铵,Copper(II) Sulfate体系中,用 甲醇,水 用作溶剂,化学反应 27.0H,反应生成1-(4-吡啶基)哌嗪
参考文献:具有中心烟碱作用的n1-乙酰基-N4-二甲基-哌嗪碘化物(admp)和n1-苯基-N4-二甲基-哌嗪碘化物(dmpp)的杂交和等距类似物.
标题:具有中心烟碱作用的n1-乙酰基-N4-二甲基-哌嗪碘化物(admp)和n1-苯基-N4-二甲基-哌嗪碘化物(dmpp)的杂交和等距类似物.
摘要:通过将n1-乙酰基-N4-二甲基哌嗪碘化物(1,Admp)和n1-苯基-N4-二甲基哌嗪碘化物(3,Dmpp)或相应的叔碱基(2,4)用槟榔碱(5)和槟榔酮(6)或通过等规取代dmpp的苯环.杂交提供了既作为叔碱又作为碘甲基化物的化合物,其对烟碱样受体没有亲和力.相反,等位取代使化合物对受体保持亲和力.其中,两个叔碱基(37,38)对烟碱样受体具有纳摩尔级的亲和力.这些异构化合物的药理学特征非常有趣,因为它们的外周和中枢作用存在差异,
Doi:10.1016/s0968-0896(98)00259-4

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-2007021436-A1
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

专利号:CA-2611219-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:AU-2006258056-A1
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:US-9751851-B2
优先权日:2013-09-20
标 题:Molecules and compositions that inhibit gram negative bacteria and their uses
发明人：BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T
权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T
摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.