CAS: 100846-24-0; 5-(Trifluoromethyl)Indole

相似化合物

13544-43-9 128562-95-8 172217-02-6

上下游产品

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4-硝基三氟甲苯置于potassium Tert-Butylate,氢气体系中,用 N,N-二甲基甲酰胺 用作溶剂,-24.0~20.0 °C,101.33 Kpa 条件下,反应 26.5H,反应生成5-(三氟甲基)吲哚
参考文献:Co-Rh异双金属纳米粒子与大气氢在温和条件下通过2-(2-硝基芳基)乙腈的还原环化反应对吲哚进行活性和可循环催化合成
标题:Co-Rh异双金属纳米粒子与大气氢在温和条件下通过2-(2-硝基芳基)乙腈的还原环化反应对吲哚进行活性和可循环催化合成
摘要:钴-铑异双金属纳米粒子催化的2-(2-硝基芳基)乙腈还原环化成吲哚.在温和条件下(1 Atm H 2和25oc),串联反应在没有任何添加剂的情况下进行.该过程可以按比例放大至克级.在这些反应条件下,催化体系非常稳定,可以重复使用十次以上,而不会损失催化活性.
Doi:10.1021/acs.Orglett.6B02659

专利信息

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:US-2016229847-A1
优先权日:2013-10-04
标 题:Novel bicyclic pyridinones as gamma-secretase modulators
发明人：PETTERSSON MARTIN YOUNGJIN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; JOHNSON DOUGLAS SCOTT; KAUFFMAN GREGORY WAYNE; O'DONNELL CHRISTOPHER WILLIAM; PATEL NANDINI CHATURBHAI; STEPAN ANTONIA FRIEDERIKE; STIFF CORY MICHAEL; SUBRAMANYAM CHAKRAPANI; TRAN TUAN PHONG; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula II as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-118056825-A
优先权日:2022-11-21
标题:A vilazodone derivative and its synthesis method and application in the preparation of anti-tumor drugs

专利号:CN-118164894-A
优先权日:2024-03-13
标 题 :Synthesis method of 3-aminoindole compound

专利号:CN-113444031-B
优先权日:2020-03-25
标 题:Synthesis method of 2, 2-diaryl acetonitrile compound