2-Bromo-5-[methoxy(Phenyl)Methyl]Thiophene置于盐酸体系中,用 二甲基亚砜 用作溶剂,化学反应 25.0H,反应生成2-苯甲酰噻吩 参考文献:Barker,John M.; Huddleston,Patrick R.; Clephane,Janette,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 275-282 标题:Barker,John M.; Huddleston,Patrick R.; Clephane,Janette,Journal Of The Chemical Society. Perkin Transactions I,1985,P. 275-282
专利号:US-8212056-B2 优先权日:2008-06-30 标 题 :Ligands for transition-metals and methods of use 发明人:KWONG FUK YEE; SO CHAU MING 权利人:KWONG FUK YEE; SO CHAU MING; UNIV HONG KONG POLYTECHNIC 摘要:The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.
专利号:US-6683205-B2 优先权日:2001-02-15 标 题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs 发明人:HOSSAIN M MAHMUN 权利人:WISYS TECHNOLOGY FOUND INC 摘要:A method of producing a compound of the formula: n and its pharmaceutically acceptable salts, wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic group; comprising: n (1) reacting a compound of the formula: n wherein Ar is as described above, with N 2 CHCOOR, wherein R is alkyl, in the presence of a catalytic amount of a Bronsted acid or Lewis acid to form a compound of the formula: n wherein Ar and R are as described above; and n (2) reacting the compound of formula (II) with a reducing agent in the presence of an alkyl amine to form a compound of the formula: n wherein Ar and R are as described above.
专利号:US-4845243-A 优先权日:1986-12-23 标 题 :Intermediates and their use in the synthesis of organic compounds 发明人:GIORDANO CLAUDIO; CASTALDI GRAZIANO 权利人:ZAMBON SPA 摘要:Compounds of formula ##STR1## (wherein Ar, R, R 1 and X have the meanings reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.
专利号:EP-0178580-B1 优先权日:1984-10-15 标题:Intermediates for the synthesis of carboxylic acids 摘要:The compounds of formula: in which Ar represents an aryl, possibly substituted; R represents a C1-C4 alkyl; X represents a hydrogen, chlorine, bromine or iodine atom, a hydroxyl, or an acyloxy, alkylsulphonyloxy or arylsulphonyloxy group; n represents 0 or 1, where if n=0 one of R1 and R2 represents a -CH2OH group and the other represents a hydrogen atom, and if n=1 both R1 and R2 represent hydrogen atoms; are useful intermediates in the preparation of alpha-arylalkanoic acids by rearrangement reactions. The compounds of formula I are prepared by reacting glycerin or one of its anlogues with the appropriate alkyl-aryl-ketone.
专利号:US-5274186-A 优先权日:1986-12-23 标 题 :Intermediates and their use in the synthesis of organic compounds 发明人:GIORDANO CLAUDIO; CASTALDI GRAZIANO 权利人:ZAMBON SPA 摘要:Compounds of formula ##STR1## (wherein Ar, R, R 1 and X have the meaning reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.
专利号:US-4734507-A 优先权日:1984-04-06 标 题:Optically active ketals, processes for their preparation and their use in the synthesis of alpha-arylalkanoic acids
1: Gedik Z, Tugrak M, Dastan A, Gul HI, Yilmaz D. Radiation Parameters of Some Potential Bioactive Compounds. Guang Pu Xue Yu Guang Pu Fen Xi. 2015 Jun;35(6):1501-5. doi: 10.1080/14756360802399126.
合成参考文献
摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 379. 摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 377. 摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 379. 摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 115. 摘要:Gosmini, C.; Corpet, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 706.