CAS: 15399-22-1; (S)-Methyl 2-Aminobutanoate

相似化合物

56545-22-3 7682-18-0 85774-09-0

上下游产品

methanol L-2-aminobutyric acid N-benzyloxycarbonyl-L-α-vinylglycine methyl ester diazomethaneα-Z-Nε-B°C-L-Lysyl>-L-α-amino-buttersaeure-methylesterα-Z-Nε-B°C-L-Lysyl-L-α-amino-buttersaeure-methylester (3S,6S)-3,6-diethylpiperazine-2,5-dione S-(+)-2-amino-n-butyric acid hydr°Chloride (S)-2-amino-butanamide hydr°Chloride

L-蛋氨酸甲酯盐酸盐置于raney Nickel体系中,用 水 用作溶剂,化学反应 4.0H,以64%的收率获得(S)-2-氨基丁酸甲酯
参考文献:用于合成抗癫痫和抗结核活性药物成分的对映体纯中间体的连续流方案
标题:用于合成抗癫痫和抗结核活性药物成分的对映体纯中间体的连续流方案
摘要:手性中间体的连续流生产在活性药物成分(api)的基础材料的开发中起着重要作用,因为α-氨基酸及其衍生物被广泛用作基础材料.在这项工作中,我们开发了两种用于合成左乙拉西坦/溴乙酰胺和乙胺丁醇的中间体的合成策略.获得的结果表明,通过raney®镍脱硫/还原策略,蛋氨酸甲酯可连续转化为所需的乙胺丁醇中间体,而raney®镍(无h 2)和pd / C-h 2均可合成左乙拉西坦/溴乙酰胺中间体.途径或通过光化学脱硫.
Doi:10.1039/c8Ob03088J

专利信息

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:US-6627431-B1
优先权日:2000-05-12
标 题 :Chemoenzymatic synthesis of neotame
发明人：PRAKASH INDRA; ZHAO ROBERT Y
权利人:NUTRASWEET CO
摘要:A chemoenzymatic method is disclosed for preparing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester via the enzymatic regioselective hydrolysis of neotame esters using lipases or esterases.

专利号:US-8288561-B2
优先权日:2007-05-07
标 题:Process for preparing valsartan
发明人：KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR
权利人:KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR; CIPLA LTD
摘要:An N-[(2′-(1-triphenyl methyl tetrazole-5-yl)biphenyl]-4-yl]methyl]-L-valine benzyl ester organic salt of formula (IVA) wherein A represents an organic carboxylic acid, a process for its preparation and its use in the synthesis of valsartan or salts thereof.

专利号:CN-112195203-B
优先权日:2020-11-10
标题 :A kind of method for enzymatic synthesis of (S)-2-aminobutanamide

专利号:CN-104341450-B
优先权日:2013-08-09
标题 :A kind of synthesis of phosphocreatine derivative and pharmaceutical applications

专利号:WO-2021236859-A1
优先权日:2020-05-22
标题 :Synthesis of fluorinated nucleotides