CAS: 2040-90-6; 2-Chloro-6-Fluorophenol

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CAS号53145-38-3 2-氯-6-氟苯甲醚 | CAS号1228447-85-5 (2-chloro-6-flu... | CAS号367-12-4 2-氟苯酚 | CAS号220991-20-8 罗美昔布 | CAS号53145-38-3 2-氯-6-氟苯甲醚 | CAS号332903-74-9 (2-氯-6-氟苯基)-对甲苯胺 | CAS号938180-34-8 2-(苄氧基)-1-氯-3-氟苯

邻氯苯酚置于2-吡啶甲酸,Potassium Phosphate,Copper(L) Iodide,N-氟代双苯磺酰胺,三氟甲烷磺酸甲酯,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 二甲基亚砜,乙酸乙酯,甲苯 用作溶剂,化学反应 32.0H,反应生成2-氯-6-氟苯酚
参考文献:一种合成2-氟代苯酚化合物的方法
标题:一种合成2-氟代苯酚化合物的方法
摘要:本发明提供了一种合成式iv所示的2‑氟代苯酚化合物的方法:式i所示苯酚化合物经过乌尔曼反应制得式ii所示2‑吡啶氧基芳烃化合物,式ii所示2‑吡啶氧基芳烃化合物与钯催化剂,氟化试剂,添加剂,有机溶剂混合,在30~160oc温度下搅拌进行氟化反应,制得式iii所示的邻位氟化的2‑吡啶氧基芳烃化合物,式iii所示的邻位氟化的2‑吡啶氧基芳烃化合物通过碱的作用制得式iv所示的2‑氟代苯酚化合物.本发明方法具有反应条件温和,操作简单,底物适应性好,氟化选择性高等优点.

专利信息

专利号:WO-2009081259-A1
优先权日:2007-12-21
标题 :Phenoxy-pyridyl derivatives
发明人：BARTA NANCY SUE; CAMPBELL BRIAN MICHAEL; DOUNAY AMY BETH; GRAY DAVID LAWRENCE FIRMAN; ZORN STEVIN HOWARD
权利人:PFIZER; BARTA NANCY SUE; CAMPBELL BRIAN MICHAEL; DOUNAY AMY BETH; GRAY DAVID LAWRENCE FIRMAN; ZORN STEVIN HOWARD
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.