CAS: 27063-90-7; 5-Bromo-2,3-Dimethylpyridine

该化合物是卤化的丙烯衍生物,在2-3个位置的5个位置和甲基组中具有溴替代作用,该化合物是有机合成的多用途中间体,特别是在制药和农用化学应用方面,其溴基能通过交叉反应进一步发挥作用,而二甲基丙烯丙烯基磺片则有助于对目标分子进行静态和电子调控.该化合物在标准条件下具有良好的稳定性,便于处理和储存.其定义明确的结构和再活动使得它对于建造复杂的循环循环系统或作为药用化学研究的构件具有价值.

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117846-56-7 17117-19-0 156072-86-5

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CAS号583-61-9 2,3-二甲吡啶

合成工艺路线路线简述

    2,3-二甲基吡啶置于硫酸,溴体系中,用8.3 G的收率获得2,3-二甲基-5-溴吡啶
    参考文献:Beta-Lactamase Inhibitors
    标题:Beta-Lactamase Inhibitors
    摘要:本文描述了调节β-内酰胺酶活性的化合物和组合物.在某些实施例中,所述化合物抑制β-内酰胺酶.在特定实施例中,所述化合物在治疗细菌感染方面是有用的.

    海关参考信息

    专利信息


    专利号:WO-2023086799-A1
    优先权日:2021-11-09
    标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
    发明人:HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
    权利人:VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

    专利号:BR-112019014061-A2
    优先权日:2017-01-23
    标 题 :compounds of formula i, intermediates b, intermediates c, intermediates ii and intermediates d, composition, use, method to combat phytopathogenic fungi, seed and process for the synthesis of the compounds of formula i

    专利号:US-2001053850-A1
    优先权日:2000-05-23
    标题 :Novel synthesis of heteroarylamine intermediate compounds

    专利号:US-2024199548-A1
    优先权日:2021-03-26
    标题 :Novel compounds useful as sting agonists and uses thereof
    发明人:YE YANG; LI XIUWEI; YANG GUIQUN; YAN FASHUN; WANG YANPING; LONG WEI
    权利人:JACOBIO PHARMACEUTICALS CO LTD
    摘要:Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.

    专利号:US-2025108123-A1
    优先权日:2021-12-17
    标 题:Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof
    发明人:YE YANG; LI XIUWEI; YANG GUIQUN; WANG HONGLING; FANG XIONG; CUI YANKAI; YAN FASHUN; SONG BINHUA
    权利人:JACOBIO PHARMACEUTICALS CO LTD
    摘要:Provided herein are compound-linker constructs and antibody-drug-conjugates of compounds of formula (Y-1), (Y-2), (Y-3), (A), (B), (C), I, II, III, IV or V that are useful as modulators of STING (Stimulator of Interferon Genes). Also provided are synthesis, compositions and uses of such compound-linker constructs and antibody-drug-conjugates.

    专利号:WO-2024115549-A1
    优先权日:2022-11-30
    标题:Aryl- and heteroaryl-sulfonamide derivatives as ccr8 modulators
    发明人:AISSAOUI HAMED; CORMINBOEUF OLIVIER; DIETHELM STEFAN; REMEN LUBOS; RICHARD-BILDSTEIN SYLVIA
    权利人:IDORSIA PHARMACEUTICALS LTD
    摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR8 receptor modulators in medicine.
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    合成参考文献


    摘要:Liao, L.; Zhang, Y.; Yu, J.-S., Science of Synthesis: Knowledge Updates, (2024) 1, 219.
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