CAS: 3279-90-1; 6-Bromo-3,4-Dihydro-1H-Quinolin-2-One

相似化合物

14548-51-7 880094-83-7 1404367-56-1

上下游产品

6-溴-1,2,3,4-四氢喹啉 6-Bromo-1,2,3,4-Tetrahydroquinoline 22190-35-8
3,4-二氢-2(1H)-喹啉酮 3,4-Dihydro-2(1H)-Quinolone 553-03-7
6-Bromo-1-Hydroxy-3,4-Dihydroquinolin-2(1H)-One 125076-71-3
7-氨基-3,4-二氢-1H-喹啉-2-酮 7-Amino-3,4-Dihydro-2(1H)-Quinolinone 22246-07-7
7-Acetylamino-3,4-Dihydro-1H-Quinolin-2-One 22246-08-8

5-溴茚酮置于sodium Azide,硫酸体系中,用 苯 作为反应溶剂,化学反应 0.33H,反应生成 6-溴-1,2,3,4-四氢-2-喹啉酮
参考文献:Biarylmethyl Indolines,Indoles And Tetrahydroquinolines,Useful As Serine Protease Inhibitors
标题:Biarylmethyl Indolines,Indoles And Tetrahydroquinolines,Useful As Serine Protease Inhibitors
摘要:本发明提供了formula (I)的化合物:1或其立体异构体或药用可接受的盐或水合物形式,其中变量a,B,L1,L2,X1,X2,X3,X4和w如本文所定义.formula (I)的化合物可作为凝血级联和/或接触激活系统的丝氨酸蛋白酶酶的选择性抑制剂,例如凝血酶,因子xa,因子xia,因子ixa,因子viia和/或血浆激肽.具体地,涉及具有选择性因子xia抑制剂的化合物.本发明还涉及包含这些化合物的药物组合物以及使用这些药物组合物治疗血栓栓塞性和/或炎症性疾病的方法.

专利信息

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.