CAS: 394-32-1; 1-(5-Fluoro-2-Hydroxyphenyl)Ethanone

上下游产品

CAS号405-51-6 4-氟苯基醋酸酯 | CAS号445-82-9 5-氟-2-甲氧基苯乙酮 | CAS号371-41-5 4-氟苯酚 | CAS号75-36-5 乙酰氯 | CAS号64-19-7 冰醋酸 | CAS号459-60-9 4-氟苯甲醚 | CAS号459-26-7 4-氟苯乙醚 | CAS号189628-38-4 5-氟-2-甲氧基苯腈 | CAS号7446-70-0 氯化铝 | CAS号345-16-4 5-氟水杨酸 | CAS号394-04-7 5-氟-2-甲氧基苯甲酸 | CAS号445-82-9 5-氟-2-甲氧基苯乙酮 | CAS号303176-40-1 (1’R,2S)-2-(2’-... | CAS号303176-39-8 (1’R,2S)-2-(1’,... | CAS号303176-46-7 (1’R,2R)-2-(2’-... | CAS号99199-90-3 6-氟-2-(环氧乙烷-2H)... | CAS号99199-59-4 6-氟-4-氧代-4氢-1-苯... | CAS号874649-82-8 6-氟色满-2-羧酸甲酯 | CAS号88754-96-5 6-氟-2-甲基苯并二氢吡喃-4-酮

4-氟苯基醋酸酯置于盐酸,Aluminum (Iii) Chloride体系中,用 水 作为反应溶剂,以92%的收率获得产物5-氟-2-羟基苯乙酮
参考文献:2,5-二取代的1,3,4-恶二唑衍生物的合成及其体外抗炎,抗氧化作用及分子对接研究.
标题:2,5-二取代的1,3,4-恶二唑衍生物的合成及其体外抗炎,抗氧化作用及分子对接研究.
摘要:通过环化合成了一系列新颖的2,5-二取代的1,3,4-Oxadiazole衍生物作为潜在的抗炎药和抗氧化剂.采用传统方法,在三氯氧磷(pocl3)存在下,用取代酸处理过的酰肼分子是一种有效的试剂和溶剂,化学反应时间短,产率高.与标准药物相比,新合成的1,3,4-恶二唑衍生物表现出优异的抗炎和抗氧化活性.对关键的抗炎靶标环氧合酶2(cox-2)的分子对接研究表明,支架能够正确识别活性位点,并与其中的关键残基实现显着的键合和非键合相互作用.
DOI:10.1016/j.Bmcl.2020.127136

专利信息

专利号:US-8633241-B2
优先权日:2004-07-30
标 题:Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
发明人：ATTANTI SRINIVASARAO VEERAVENKATA; PATEL HASMUKH MATHURBHAI; NADKARNI SUNIL SADANAND
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:The present invention provides an improved process for the synthesis of nebivolol or its pharmaceutically acceptable salts, more particularly hydrochloride salt of formula (I). n n n n n n n n n n The present invention further provides a new Form T1 of nebivolol and its pharmaceutically acceptable salts. n The present invention also provides pharmaceutical compositions and process for the preparation of a solid oral dosage form of nebivolol hydrochloride of formula (I), without the use of wetting agent, and optionally using binder and/or disintegrant.

专利号:WO-2004058727-A1
优先权日:2002-12-20
标题 :Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
发明人：CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
权利人:BAYER PHARMACEUTICALS CORP; CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
摘要:This invention relates to substituted 3,5-dihydro-4H-imidazol-4-ones compounds which are useful in the treatment of obesity and obesity-related disorders, and as weight-loss and weight-control agents. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-6384060-B1
优先权日:1997-12-11
标 题 :2,4,6-trisbstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
发明人：CHIU CHINGFAN; TANG ZHILIAN; ELLINGBOE JOHN W
权利人:AMERICAN HOME PROD
摘要:The present invention relates to novel substituted pyridine compounds of Formula (I) n wherein the moiety Z, R 1 , R 2 and R 3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.

专利号:EP-1491540-B1
优先权日:2001-03-30
标题 :Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors

专利号:US-6737434-B2
优先权日:2000-09-22
标 题 :Imidazole derivatives or their salts
发明人：TOKIZAWA MINORU; TAKEDA SUNAO; KANEKO YASUSHI; KUSANO KOJI; ETO HIROMICHI; TACHIBANA KOICHI; SATO SUSUMU; TANIYAMA TADAYOSHI
权利人:SSP CO LTD
摘要:Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R 1 is lower alkyl; R 2 is alkyl or aralkyl; and X 1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.

专利号:US-6503917-B1
优先权日:1998-12-10
标题 :2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
发明人：CHIU CHINGFAN; TANG ZHILIAN; ELLINGBOE JOHN W
权利人:WYETH FIVE GIRALDA FARMS
摘要:The present invention relates to novel substituted pyridine compounds of Formula (I)wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, to methods of treatment and to pharmaceutical compositions thereof.