CAS: 394-50-3; 3-Fluoro-2-Hydroxybenzaldehyde

上下游产品

CAS号109-72-8 正丁基锂 | CAS号98015-07-7 2-(2-溴-5-甲氧基苯基)... | CAS号106-49-0 对甲苯胺 | CAS号67-66-3 氯仿 | CAS号367-12-4 2-氟苯酚 | CAS号2105-94-4 4-溴-2-氟苯酚 | CAS号1526-17-6 2-氟-6-硝基苯酚 | CAS号403-19-0 2-氟-4-硝基苯酚 | CAS号399-96-2 4-氨基-2-氟苯酚 | CAS号484-94-6 2-氟-6-硝基苯甲醚 | CAS号341-27-5 3-氟水杨酸 | CAS号24410-61-5 7-氟苯并呋喃 | CAS号74266-68-5 3-氟-2-甲氧基苯甲醛 | CAS号363-52-0 3-氟邻苯二酚 | CAS号251300-28-4 5-溴-3-氟-2-羟基苯甲醛 | CAS号749929-50-8 Benzenemethanol... | CAS号443-90-3 2-甲基-6-氟苯酚

4-溴-2-氟-6-硝基苯甲醚置于palladium On Activated Charcoal 氢氧化钾,氢溴酸,氢气体系中,用 甲醇 用作溶剂,化学反应 5.5H,反应生成3-氟-2-羟基苯甲醛
参考文献:Aymes,Daniel J.; Paris,Michel R.,Bulletin De La Societe Chimique De France,1980,Vol. 2,# 3-4,P. 175-178
标题:Aymes,Daniel J.; Paris,Michel R.,Bulletin De La Societe Chimique De France,1980,Vol. 2,# 3-4,P. 175-178

专利信息

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:US-3972945-A
优先权日:1974-12-23
标 题:Process for the selective synthesis of salicylaldehydes
发明人：ALBRIGHT CHARLES F
权利人:GARRETT CORP
摘要:The classical Reimer-Tiemann reaction for the synthesis of phenolic aldehydes has been modified from an aqueous to a non-aqueous system to provide an improved route for the formation of salicylaldehydes and, preferably, 3-substituted salicylaldehydes, e.g. 3-fluorosalicylaldehyde. Heretofore, compounds such as 3-substituted salicylaldehydes have proven to be extremely difficult to prepare in other than small laboratory quantities from the corresponding ortho-substituted phenol, since, in the final salicylaldehyde, each position ortho to the hydroxyl group contains substitution. In particular, with respect to 3-fluorosalicylaldehyde, one of the positions is occupied by the strongly electronegative fluorine atom so that the principal reaction product in the aqueous Reimer-Tiemann reaction has always been the para-isomer (3-fluoro-4-hydroxy-benzaldehyde), only negligible quantities of the desired ortho-isomer being obtained. In the process of the present invention, o-fluorophenol is caused to react with sodium hydroxide and chloroform in a hydrocarbon diluent (preferably benzene), maintaining the reaction under essentially anhydrous conditions by taking up the water of reaction with excess sodium hydroxide. It is necessary that an aprotic solvent, such as N,N-dimethylformamide, be employed as a catalyst. The use of boron oxide, while not absolutely necessary to the reaction, has been found to be advantageous in that the reaction proceeds more smoothly if the phenoxyboroxine is formed initially. The boron oxide also acts as a dehydrating agent and aids in removing the water of reaction. The preferential reaction product is the desired 3-fluorosalicylaldehyde, no paraisomer having been found. After hydrolysis and neutralization, the 3-fluorosalicylaldehyde can be recovered by azeotropic distillation along with a substantial quantity of unreacted o-fluorophenol which can be purified for recycle in subsequent preparations.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:EP-0861223-B1
优先权日:1995-11-03
标 题:Process for the synthesis of curcumin-related compounds

专利号:WO-9716403-A1
优先权日:1995-11-03
标 题 :Process for the synthesis of curcumin-related compounds

专利号:EP-0861223-A1
优先权日:1995-11-03
标 题 :Process for the synthesis of curcumin-related compounds