Methyl Imini Ester Hydrochloride Of Butyric Acid置于甲醇体系中,化学反应生成 原丁酸三甲酯 参考文献:Brooker; White,Journal Of The American Chemical Society,1935,Vol. 57,P. 2485 标题:Brooker; White,Journal Of The American Chemical Society,1935,Vol. 57,P. 2485
专利号:US-8115002-B2 优先权日:2006-09-20 标 题:Preparation of substituted morphinan-6-ones and salts and intermediates thereof 发明人:WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W 权利人:WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W; MALLINCKRODT LLC 摘要:The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.
专利号:EP-4342918-A1 优先权日:2022-09-21 标 题:Process for the synthesis of sterically crowded and synthetically challenging alkyl alkoxy silanes using organolithium reagents 发明人:SENTHIL KUMAR MINOR; PAGHABAR BHARATKUMAR RAVJI 权利人:SABIC GLOBAL TECHNOLOGIES BV 摘要:A process for the preparation of mono- or di- alkyl alkoxy silanes according to Formula 3 or Formula 5, said process comprising the following step i) contacting an alkoxy silane according to formula 2 with an organolithium reagents according to Formula 1 to form a mono- or di- alkyl alkoxy silanes according to formula 3 and lithium compound according to formula 4
专利号:US-2005215801-A1 优先权日:2002-06-28 标 题 :Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for synthesis thereof and process for preparation of the intermediates 发明人:KITAJIMA KUMI; NAGASHIMA NOBUO 权利人:KITAJIMA KUMI; NAGASHIMA NOBUO 摘要:The present invention provides an industrial process for effectively and advantageously preparing optically active 1-substituted amino-2,3-epoxypropanes useful as intermediates for preparing agricultural chemicals and medical products from optically active 1-substituted amino-2,3-propanediols used as raw materials. The present invention also provides useful intermediates. Specifically, an optically active 1-substituted amino-2,3-propanediol (1) is reacted with an orthoacid ester (2) or thionyl chloride (3) to produce a cyclic optically active compound (4), and then a compound (5) containing a halogen atom is prepared by reaction with a ring-opening reaction agent having an ability to introduce a halogen atom X. Finally, an optical active 1-substituted amino-2,3-epoxypropane is prepared by ring-closure reaction in the presence of a base.
专利号:US-4990602-A 优先权日:1986-12-17 标 题:Erythromycin A derivatives 发明人:MORIMOTO SHIGEO; ADACHI TAKASHI; MATSUNAGA TOHRU; KASHIMURA MASATO; ASAKA TOSHIFUMI; WATANABE YOSHIAKI; SOTA KAORU; SEKIUCHI KAZUTO 权利人:TAISHO PHARMACEUTICAL CO LTD 摘要:Erthromycin A derivatives represented by the general formula ##STR1## wherein R 1 is a group of the formula R 7 CH 2 -- (wherein R 7 is a hydrogen group or a lower alkyl group) or a group of the formula R 8 O-- (wherein R 8 is a lower alkyl group), R 2 is R 8 , a cycloalkyl group, a phenyl group or an aralkyl group.), or R 2 and R 7 together form an alkylene group, R 3 is a hydrogen atom, a lower alkyl group, a phenyl group or an aralkyl group, or R 3 and R 7 together form an alkylene group, or R 2 and R 3 together form an alkylene group, R 4 is a lower alkyl group, R 5 is a substituted silyl group, and R 6 is a hydrogen atom or R 5 , are disclosed. These compounds are useful as intermediates for the synthesis of antibacterial agents.
专利号:US-5030457-A 优先权日:1989-08-28 标 题 :Bioerodible polymers useful for the controlled release of therapeutic agents 发明人:NG STEVE Y W; HELLER JORGE 权利人:PHARMACEUTICAL DELIVERY SYSTEM 摘要:Bioerodible ortho ester polymers useful for preparing soft form bioerodible pharmaceutical compositions such as ointments, creams, gels and the like are provided. A novel synthetic method for preparing the polymers is provided as well. Synthesis involves a one-step reaction between a monomeric ortho ester and a triol. The pharmaceutical compositions of the invention are useful for the controlled release of therapeutic agents, and may be administered for a variety of purposes, such as for the treatment of deep wounds, including burns, and for the treatment of periodontal disease.
专利号:US-4999451-A 优先权日:1974-09-10 标题:Process for preparing dihalovinylcyclopropanecarboxylates 发明人:KONDO KIYOSHI; MATSUI KIYOHIDE; NEGISHI AKIRA; TAKAHATAKAE YURIKO 权利人:SAGAMI CHEM RES 摘要:Novel synthesis of dihalovinylcyclopropanecarboxylates, including potent insecticides, are described. The processes begin with the reaction between an alkenol and an orthoester to produce a γ-unsaturated carboxylate, followed by the catalyzed addition of a carbon tetrahalide to the double bond and dehydrohalogenation to produce a cyclopropane derivative.
[参考文献]: E Shapiro, Et Al. 17-Esters And 17,21-Diesters Of 9-Alpha, 11-Beta-Dichlorocorticoids. Synthesis And Anti-Inflammatory Activity. Steroids. 1967 Feb;9(2):143-56. [参考文献]: H Ogura, Et Al. Synthesis Of 9-O-Acyl- And 4-O-Acetyl-Sialic Acids. Carbohydr Res. 1987 Sep 15:167:77-86.
合成参考文献
摘要:Chemla, F.; Ferreira, F.; Pérez-Luna, A., Science of Synthesis Knowledge Updates, (2012) 1, 439.